Asymmetry Ventures logo

Asymmetry Ventures

North America, California, United States, San Francisco

Description

Asymmetry Ventures is a San Francisco-based early-stage venture capital firm dedicated to investing in defensible businesses. Established around 2021-2022, the firm focuses on providing capital to pre-seed and seed-stage startups. Its investment thesis centers on identifying companies with strong competitive advantages, often derived from proprietary technology, unique business models, or significant network effects, aiming to support their growth from the earliest stages.

The firm targets a diverse range of sectors, including software, fintech, artificial intelligence, healthcare, consumer technology, and the future of work, reflecting a broad interest in technology-driven innovation. Asymmetry Ventures typically writes initial checks ranging from $500,000 to $1.5 million, positioning itself as a key early financial partner for nascent companies. This strategic check size allows them to be a meaningful contributor in seed rounds while maintaining a diversified portfolio.

In October 2022, Asymmetry Ventures successfully closed its debut fund, securing $20 million in capital commitments. This fund empowers the firm to make approximately 10-20 initial investments, with reserves allocated for follow-on funding to support their most promising portfolio companies through subsequent growth stages. The firm's approach emphasizes active partnership with founders, leveraging its expertise and network to help startups navigate early challenges and scale effectively.

Asymmetry Ventures seeks to back founders who are building resilient companies capable of withstanding market fluctuations and competitive pressures. Their commitment to early-stage funding underscores a belief in identifying and nurturing foundational technologies and business models that can achieve significant long-term impact and returns.

Investor Profile

Asymmetry Ventures has backed more than 197 startups, with 5 new investments in the last 12 months alone. The firm has led 3 rounds, about 2% of its total and boasts 5 exits across its portfolio.

Investment Focus Highlights

  • Concentrates on Seed, Pre Seed, Series A rounds (top funding stages).
  • Majority of deals are located in United States, India, Canada.
  • Strong thematic focus on Software, Health Care, Biotechnology.
  • Typical check size: $500K – $1.5M.

Stage Focus

  • Seed (77%)
  • Pre Seed (12%)
  • Series A (7%)
  • Series C (1%)
  • Convertible Note (1%)
  • Series Unknown (1%)
  • Series D (1%)
  • Series B (1%)

Country Focus

  • United States (74%)
  • India (6%)
  • Canada (4%)
  • United Kingdom (3%)
  • Mexico (2%)
  • Nigeria (2%)
  • Kenya (1%)
  • Vietnam (1%)
  • Thailand (1%)
  • Israel (1%)

Industry Focus

  • Software
  • Health Care
  • Biotechnology
  • Artificial Intelligence (Ai)
  • Information Technology
  • Manufacturing
  • Machine Learning
  • Real Estate
  • E-commerce
  • Financial Services
circle-line
FAQ

Frequently Asked Questions

Learn who this investor regularly partners with—both firms and angels—and explore their latest activity.

Who does Asymmetry Ventures frequently co-invest with?

Gaingels
North America, Vermont, United States, Burlington
Co-Investments: 7
Techstars
North America, Colorado, United States, Boulder
Co-Investments: 7
Soma Capital
North America, California, United States, San Francisco
Co-Investments: 6
500 Global
North America, California, United States, San Francisco
Co-Investments: 5
Liquid 2 Ventures
North America, California, United States, San Francisco
Co-Investments: 7
Y Combinator
North America, California, United States, Mountain View
Co-Investments: 36
Pioneer Fund
North America, California, United States, San Francisco
Co-Investments: 11
Unpopular Ventures
North America, California, United States, San Francisco
Co-Investments: 8
Alumni Ventures
North America, New Hampshire, United States, Manchester
Co-Investments: 6
Goodwater Capital
North America, California, United States, Burlingame
Co-Investments: 12

Which angels does Asymmetry Ventures often collaborate with?

EL
North America, Florida, United States, Miami Beach
Shared Deals: 2
DT
North America, New York, United States, New York
Shared Deals: 2
JP
North America, California, United States, San Francisco
Shared Deals: 2
VR
North America, Texas, United States, Austin
Shared Deals: 6
AR
North America, California, United States
Shared Deals: 2
AH
North America, North Carolina, United States, Charlotte
Shared Deals: 1
BM
North America, California, United States, San Francisco
Shared Deals: 2
MC
North America, Texas, United States, Dallas
Shared Deals: 2
JM
North America, Texas, United States, Dallas
Shared Deals: 2
JW
North America, New York, United States, New York
Shared Deals: 5

What are some of recent deals done by Asymmetry Ventures?

Coreshell Technologies

San Leandro, California, United States

Coreshell Technologies is a nanotechnology company that is a developer of nanolayer coating technology for rechargeable batteries.

BatteryElectric VehicleManufacturingNanotechnologyRenewable Energy
Series AMar 18, 2025
Amount Raised: $24,000,000
SimCare AI

San Francisco, California, United States

SimCare AI is a healthcare technology firm that is using artificial intelligence to revolutionize clinical training.

Artificial Intelligence (AI)E-LearningHealth CareSimulation
SeedFeb 27, 2025
Amount Raised: $2,000,000
Mast Reforestation

Seattle, Washington, United States

Mast Reforestation is a tech-led reforestation company that provides seedling, project management, and carbon removal credits for forests.

CleanTechEnvironmental EngineeringForestryNatural ResourcesRenewable EnergySocial Impact
Series BFeb 11, 2025
Amount Raised: $25,000,000
Jome (formerly NewHomesMate)

Austin, Texas, United States

Jome is an AI-powered marketplace to find, compare, and buy new construction homes.

Information ServicesInformation TechnologyMarketplaceProperty DevelopmentReal EstateSoftware
Series ADec 18, 2024
Amount Raised: $9,800,000
Reforged Labs

San Francisco, California, United States

GenAI video ad and creative intelligence platform for game marketing

Advertising PlatformsArtificial Intelligence (AI)Digital MarketingGaming
SeedAug 8, 2024
Amount Raised: $3,900,000
TransCrypts

Newark, California, United States

Consumer Empowered Record Management

BlockchainDocument ManagementElectronic Health Record (EHR)Human ResourcesSoftware
Pre SeedMay 24, 2024
Amount Raised: $2,400,000
SFA Therapeutics

Jenkintown, Pennsylvania, United States

SFA Therapeutics is a developer of drugs to treat chronic inflammatory diseases.

BiotechnologyHealth CareTherapeutics
Convertible NoteNov 9, 2023
Amount Raised: $4,500,000
Rejuvenation Technologies

Mountain View, California, United States

Rejuvenation Technologies is a biotechnology company that developed nucleoside-modified TERT mRNA to safely and rapidly extend telomeres.

BiotechnologyHealth Care
SeedSep 6, 2023
Amount Raised: $10,600,000
NewHomesMate

New York, New York, United States

NewHomesMate is a marketplace to find, compare, and buy new construction homes.

Information ServicesInformation TechnologyProperty DevelopmentReal EstateSoftware
SeedJun 14, 2023
Amount Raised: $5,500,000
Mate Fertility

Los Angeles, California, United States

Mate Fertility operates tech-enabled fertility clinics that offer affordable and accessible fertility services.

FertilityHealth CareMedical
Series AMay 23, 2023
Amount Raised: $5,200,000