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Cottonwood Technology Fund

North America, New Mexico, United States, Santa Fe

Description

Cottonwood Technology Fund is an early-stage venture capital firm with a distinct focus on deep technology and hard science companies. Based in Santa Fe, New Mexico, with an additional office in Enschede, Netherlands, the firm strategically invests in disruptive technologies, often emerging as spin-outs from national laboratories and universities across both the United States and Europe. Their investment thesis centers on highly defensible intellectual property in sectors such as advanced materials, photonics, robotics, artificial intelligence, and cleantech.

The fund is known for its hands-on approach, providing not just capital but also strategic guidance and access to a robust network to help founders commercialize complex scientific breakthroughs. Cottonwood Technology Fund typically deploys initial checks ranging from $500,000 to $2.5 million, demonstrating their commitment to supporting companies from their nascent stages. They also reserve capital for follow-on rounds, indicating a long-term partnership approach with their portfolio companies as they scale.

Cottonwood has shown consistent growth in its fund sizes, reflecting increasing confidence and capacity in the deep tech ecosystem. Their first fund, Cottonwood Technology Fund I, launched in 2009 with $20 million. This was followed by Cottonwood Technology Fund II at $30 million, Cottonwood Technology Fund III at $60 million, and they are currently raising Cottonwood Technology Fund IV, targeting $100 million. This progression underscores their expanding influence and ability to back more capital-intensive deep tech ventures. Their unique dual-continent presence allows them to tap into a broader pool of innovation, particularly in areas where scientific research is strong.

Investor Profile

Cottonwood Technology Fund has backed more than 70 startups, with 4 new investments in the last 12 months alone. The firm has led 32 rounds, about 46% of its total and boasts 4 exits across its portfolio.

Investment Focus Highlights

  • Concentrates on Series A, Series B, Seed rounds (top funding stages).
  • Majority of deals are located in United States, The Netherlands, Germany.
  • Strong thematic focus on Manufacturing, Health Care, Medical.
  • Led 2 rounds in the past year.
  • Typical check size: $500K – $2.5M.

Stage Focus

  • Series A (31%)
  • Series B (19%)
  • Seed (14%)
  • Series Unknown (10%)
  • Series C (9%)
  • Convertible Note (6%)
  • Series D (4%)
  • Debt Financing (4%)
  • Series E (1%)
  • Pre Seed (1%)

Country Focus

  • United States (76%)
  • The Netherlands (23%)
  • Germany (1%)

Industry Focus

  • Manufacturing
  • Health Care
  • Medical
  • Biotechnology
  • Therapeutics
  • Automotive
  • Information Technology
  • Life Science
  • Industrial Automation
  • Telecommunications
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FAQ

Frequently Asked Questions

Learn who this investor regularly partners with—both firms and angels—and explore their latest activity.

Who does Cottonwood Technology Fund frequently co-invest with?

AS
North America, Missouri, United States, St Louis
Co-Investments: 4
Sun Mountain Capital
North America, New Mexico, United States, Santa Fe
Co-Investments: 25
AR
North America, Oklahoma, United States, Tulsa
Co-Investments: 3
EPIC Ventures
North America, Utah, United States, Salt Lake City
Co-Investments: 4
MV
North America, California, United States, San Diego
Co-Investments: 4
Caterpillar Ventures
North America, California, United States, Menlo Park
Co-Investments: 4
Riverstone Holdings
North America, New York, United States, New York
Co-Investments: 3
Chevron Technology Ventures
North America, Texas, United States, Houston
Co-Investments: 4
Tullis Health Investors
North America, Connecticut, United States, Stamford
Co-Investments: 7
Tramway Venture Partners
North America, New Mexico, United States, Albuquerque
Co-Investments: 6

Which angels does Cottonwood Technology Fund often collaborate with?

FS
North America, Utah, United States, Salt Lake City
Shared Deals: 1
Shared Deals: 1
Shared Deals: 1

What are some of recent deals done by Cottonwood Technology Fund?

inPhocal

Eindhoven, Noord-Brabant, The Netherlands

inPhocal uses a unique laser beam technology that will revolutionize the field of laser processing.

Machinery ManufacturingManufacturingService Industry
SeedJul 15, 2025
Amount Raised: $5,841,702
Orange Quantum Systems

Delft, Zuid-Holland, The Netherlands

Orange Quantum Systems offers quantum software, diagnosis, and system services.

Quantum ComputingSoftwareSoftware EngineeringTechnical Support
SeedJun 17, 2025
Amount Raised: $13,881,000
Sencure

Roden, Drenthe, The Netherlands

Sencure develops chips that helps measure electrophysiological parameters on the human body in innovative ways.

Health CareMedical Device
Series BMar 11, 2025
Amount Raised: $4,256,680
Keiron

Eindhoven, Noord-Brabant, The Netherlands

Keiron provides fully digital, contactless printing technology that replaces traditional stencil and jet printing technologies.

ManufacturingPrintingProduct Design
SeedFeb 18, 2025
Amount Raised: $1,567,229
Green Theme Technologies

Rio Rancho, New Mexico, United States

Green Theme Technologies is a developer of environmentally-friendly, dry textile finishing technology.

ChemicalManufacturingTextiles
Series CNov 6, 2024
Amount Raised: $6,000,000
Q*Bird B.V.

Delft, Zuid-Holland, The Netherlands

Secure Quantum Connectivity - Building the next generation digital infrastructure

Information Technology
SeedMay 28, 2024
Amount Raised: $2,712,824
Circular Genomics

Albuquerque, New Mexico, United States

Circular Genomics is a biotechnology and genomics company that develops RNA-based diagnostics for neurological diseases.

BiotechnologyHealth CareTherapeuticsWellness
Series AJan 23, 2024
Amount Raised: $8,300,000
Infinitum

Round Rock, Texas, United States

Infinitum is setting the bar for the next generation of motors to be better for the planet – and for people.

AutomotiveIndustrial AutomationInternet of ThingsManufacturing
Series ENov 1, 2023
Amount Raised: $221,000,018
Orange Quantum Systems

Delft, Zuid-Holland, The Netherlands

Orange Quantum Systems offers quantum software, diagnosis, and system services.

Quantum ComputingSoftwareSoftware EngineeringTechnical Support
Pre SeedSep 5, 2023
Amount Raised: $1,608,698
BioFlyte

Albuquerque, New Mexico, United States

BioFlyte is a biodefense company that commercializes a new class of fieldable biological threat collection.

BiotechnologyLife ScienceMedical
Series BAug 10, 2023
Amount Raised: $5,400,000