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DEFTA Partners

North America, California, United States, San Francisco

Description

DEFTA Partners is a well-established venture capital firm with a distinct focus on early-stage technology companies, operating from key global innovation hubs including San Francisco, Tokyo, and London. The firm has cultivated a reputation for identifying promising startups, particularly those with cross-border potential, emphasizing opportunities that bridge the US and Japanese markets. Since its inception, DEFTA Partners has committed to fostering innovation across critical technological domains, positioning itself as a strategic partner for founders navigating complex international landscapes.

The firm's investment strategy is primarily centered on Seed, Series A, and Series B funding rounds, targeting companies within the Digital Health, Artificial Intelligence/Machine Learning (AI/ML), and Cybersecurity sectors. DEFTA Partners seeks to provide not only capital but also strategic guidance and access to their extensive network, leveraging their deep industry expertise to support portfolio companies through critical growth phases. Their long-term approach is evident in their consistent engagement with companies from their initial funding stages through subsequent growth rounds, aiming to build enduring value.

With a significant track record, DEFTA Partners has made over 100 investments across its portfolio, demonstrating a broad reach within the early-stage tech ecosystem. The firm manages approximately $100 million in assets across two dedicated funds, underscoring its capacity to deploy capital strategically. This extensive investment activity has resulted in 12 successful exits, highlighting their ability to back companies that achieve significant milestones, including IPOs and strategic acquisitions. While specific first check sizes are not publicly disclosed, given their focus on Seed to Series B rounds, typical initial investments likely range from approximately $500,000 for early seed-stage ventures to around $5,000,000 for more developed Series A or early Series B opportunities, reflecting their flexible approach to early-stage funding.

Investor Profile

DEFTA Partners has backed more than 25 startups, with 0 new investments in the last 12 months alone. The firm has led 4 rounds, about 16% of its total and boasts 8 exits across its portfolio.

Investment Focus Highlights

  • Concentrates on Series A, Series B, Series Unknown rounds (top funding stages).
  • Majority of deals are located in United States, Israel.
  • Strong thematic focus on Biotechnology, Medical, Health Care.
  • Typical check size: $500K – $5M.

Stage Focus

  • Series A (52%)
  • Series B (20%)
  • Series Unknown (20%)
  • Series D (4%)
  • Seed (4%)

Country Focus

  • United States (92%)
  • Israel (8%)

Industry Focus

  • Biotechnology
  • Medical
  • Health Care
  • Software
  • Therapeutics
  • Mobile
  • Artificial Intelligence (Ai)
  • Video
  • Enterprise Software
  • Personal Health
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FAQ

Frequently Asked Questions

Learn who this investor regularly partners with—both firms and angels—and explore their latest activity.

Who does DEFTA Partners frequently co-invest with?

Hatteras Venture Partners
North America, North Carolina, United States, Durham
Co-Investments: 3
LabCorp
North America, North Carolina, United States, Burlington
Co-Investments: 3
Alexandria Venture Investments
North America, California, United States, Pasadena
Co-Investments: 2
Connecticut Innovations
North America, Connecticut, United States, Rocky Hill
Co-Investments: 2
180 Degree Capital
North America, New Jersey, United States, Montclair
Co-Investments: 3
Andera Partners
Europe, Ile-de-France, France, Paris
Co-Investments: 3
CE Ventures (CEIIF)
Asia, Hong Kong Island, Hong Kong, Hong Kong
Co-Investments: 2
Walden Venture Capital
North America, California, United States, San Francisco
Co-Investments: 3
Bios Partners
North America, Texas, United States, Fort Worth
Co-Investments: 3
AltaIR Capital
North America, California, United States, San Francisco
Co-Investments: 3

Which angels does DEFTA Partners often collaborate with?

Shmuel Cabilly
Asia, HaMerkaz, Israel, Rehovot
Shared Deals: 1

What are some of recent deals done by DEFTA Partners?

Endogena

San Francisco, California, United States

Endogena is a biotech company that develops endogenous regenerative medicines to repair and regenerate tissues and organs.

BiotechnologyMedicalTherapeutics
Series ADec 13, 2021
Amount Raised: $21,000,000
DiA Imaging Analysis

Be'er Sheva, HaDarom, Israel

DiA Imaging Analysis provides advanced AI-based ultrasound analysis smarter and accessible.

Artificial Intelligence (AI)Health CareMedicalSoftware
Series UnknownAug 24, 2021
Amount Raised: $14,000,000
Endogena

San Francisco, California, United States

Endogena is a biotech company that develops endogenous regenerative medicines to repair and regenerate tissues and organs.

BiotechnologyMedicalTherapeutics
Series AJan 28, 2021
Amount Raised: $8,000,000
Aegle Therapeutics

Miami, Florida, United States

Aegle Therapeutics is a clinical-stage regenerative medicine company that develops novel therapeutics.

BiotechnologyClinical TrialsTherapeutics
Series ASep 29, 2020
Amount Raised: $6,500,000
InformAI

Houston, Texas, United States

InformAI is an AI company that develops artificial intelligence and deep learning algorithms for healthcare applications.

Artificial Intelligence (AI)Health CareImage RecognitionInsurTechMachine LearningMedicalSoftware
SeedJun 26, 2020
Amount Raised: $1,800,000
TARA Biosystems

New York, New York, United States

TARA Biosystems Harnessing Human Biology + Data to Transform Cardiac Drug Discovery

BiotechnologyMedical
Series AJun 23, 2020
Amount Raised: $10,000,000
1World Online

Redwood City, California, United States

1World Online is a A.I.-powered platform that unifies the values of data and advertising into an all-in-one engagement driven model.

AnalyticsBig DataBlockchainEnterprise SoftwareMarket ResearchMobileSoftware
Series AFeb 21, 2020
Amount Raised: $8,475,104
Aegle Therapeutics

Miami, Florida, United States

Aegle Therapeutics is a clinical-stage regenerative medicine company that develops novel therapeutics.

BiotechnologyClinical TrialsTherapeutics
Series AJan 9, 2020
Amount Raised: $4,000,000
Actuate Therapeutics

Fort Worth, Texas, United States

Actuate Therapeutics provides advanced research for the treatment of high-impact cancers and neurodegenerative diseases.

BiotechnologyMedicalPharmaceutical
Series BNov 12, 2019
Amount Raised: $6,500,000
BioEclipse Therapeutics

San Francisco, California, United States

BioEclipse Therapeutics is a clinical-stage oncology company that develops immuno-oncology therapeutics using its proprietary technology.

BiotechnologyHealth CareOncologyTherapeutics
Series AJun 24, 2019
Amount Raised: $7,700,000