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Freeflow Ventures

North America, California, United States, Pasadena

Description

Freeflow Ventures is a Pasadena, California-based venture capital firm with a highly specialized investment focus on pre-seed and seed-stage companies. The firm distinguishes itself by exclusively backing startups that have a direct connection to the California Institute of Technology (Caltech) and NASA's Jet Propulsion Laboratory (JPL). This unique thesis positions Freeflow Ventures at the forefront of commercializing groundbreaking scientific and engineering innovations emerging from these world-renowned institutions. Their investment strategy is deeply rooted in supporting deep technology ventures, including those in areas such as aerospace, robotics, advanced materials, artificial intelligence, and biotechnology.

The firm typically provides initial capital ranging from $250,000 to $1,000,000 for its first checks, aiming to support the earliest stages of company formation and product development. Beyond capital, Freeflow Ventures offers strategic guidance, leveraging its extensive network within the Caltech and JPL ecosystems to help portfolio companies navigate the challenges of commercialization. This hands-on approach is designed to accelerate the transition of complex scientific research into viable market solutions, providing critical support for founders often emerging from academic or research backgrounds.

Freeflow Ventures plays a crucial role in fostering innovation within the Southern California deep tech landscape. By focusing on ventures with direct ties to Caltech and JPL, the firm taps into a rich pipeline of intellectual property and talent that is often overlooked by broader early-stage investors. Their commitment to these science-driven startups helps bridge the gap between cutting-edge research and commercial viability, contributing to the growth of high-impact industries. The firm's targeted approach ensures that its investments are aligned with the long-term potential of transformative technologies.

Investor Profile

Freeflow Ventures has backed more than 23 startups, with 7 new investments in the last 12 months alone. The firm has led 1 rounds, about 4% of its total and boasts 0 exits across its portfolio.

Investment Focus Highlights

  • Concentrates on Series A, Seed, Pre Seed rounds (top funding stages).
  • Majority of deals are located in United States, India.
  • Strong thematic focus on Biotechnology, Artificial Intelligence (AI), Chemical Engineering.
  • Led 1 rounds in the past year.
  • Typical check size: $250K – $1M.

Stage Focus

  • Series A (48%)
  • Seed (39%)
  • Pre Seed (9%)
  • Series B (4%)

Country Focus

  • United States (96%)
  • India (4%)

Industry Focus

  • Biotechnology
  • Artificial Intelligence (Ai)
  • Chemical Engineering
  • Medical
  • Aerospace
  • Machine Learning
  • Carbon Capture
  • Cleantech
  • Agtech
  • Analytics
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FAQ

Frequently Asked Questions

Learn who this investor regularly partners with—both firms and angels—and explore their latest activity.

Who does Freeflow Ventures frequently co-invest with?

Techstars
North America, Colorado, United States, Boulder
Co-Investments: 3
CI
North America, California, United States, Berkeley
Co-Investments: 2
Expon Capital
Europe, Luxembourg, Luxembourg, Luxembourg
Co-Investments: 3
Cultivation Capital
North America, Missouri, United States, St Louis
Co-Investments: 3
Caltech
North America, California, United States, Pasadena
Co-Investments: 2
Bold Capital Partners
North America, California, United States, Santa Monica
Co-Investments: 3
ER
North America, Oklahoma, United States, Tulsa
Co-Investments: 2
Santa Barbara Venture Partners
North America, California, United States, Santa Barbara
Co-Investments: 3
Aramco Ventures
Asia, Ash Sharqiyah, Saudi Arabia, Dhahran
Co-Investments: 2
OTB Ventures
Europe, Noord-Holland, The Netherlands, Amsterdam
Co-Investments: 2

Which angels does Freeflow Ventures often collaborate with?

RS
Asia, Maharashtra, India, Mumbai
Shared Deals: 1

What are some of recent deals done by Freeflow Ventures?

Mitico

Los Angeles, California, United States

Mass Mitigation of Carbon Emissions

Carbon CaptureChemical EngineeringSustainability
SeedFeb 25, 2025
Amount Raised: $4,300,000
MIIST Therapeutics

Alameda, California, United States

MIIST Therapeutics is a pulmonary drug delivery system and digital platform that enhances the science of inhaled drugs.

Health CareMedicalPharmaceutical
SeedFeb 5, 2025
Amount Raised: $7,000,000
Aralez Bio

Emeryville, California, United States

Aralez Bio uses engineered enzymes to make valuable products in a sustainable way.

BiotechnologyChemical EngineeringMedical
Series AOct 29, 2024
Amount Raised: $12,000,000
Persperity Health

Los Angeles, California, United States

Persperity Health is pioneering the future of women's health with cutting-edge, non-invasive technology that tracks female hormones.

Health CareMedicalWellness
Pre SeedOct 28, 2024
Amount Raised: $1,000,000
Esperto Medical

Orange, California, United States

Esperto's patented technology uses sound waves to measure blood pressure without an inflating cuff

Health DiagnosticsMedical Device
Series AOct 24, 2024
Calicat

Chatsworth, California, United States

Calicat is a clean-energy company developing a proprietary electrocatalyst discovery process for electrolyser.

Clean EnergyCleanTechEnergyGreenTechRenewable Energy
Series AOct 23, 2024
Amount Raised: $3,000,000
Curry it

New Delhi, Delhi, India

Curry it is a food manufacturing company that offers ready-to-cook curries, pastes, and mixes for vegetarian and non-vegetarian recipes.

CookingFood and BeverageManufacturing
SeedAug 5, 2024
Amount Raised: $535,696
Holoclara

Los Angeles, California, United States

Holoclara is a immunotherapy company that offers autoimmune disorders with nematode derived molecules.

Therapeutics
Series AJun 27, 2024
Amount Raised: $16,000,000
StrokeDx

Pasadena, California, United States

StrokeDx develops rapid and portable devices to transform how strokes are diagnosed.

Artificial Intelligence (AI)Machine LearningMedicalMedical DeviceSensor
SeedMay 23, 2024
Amount Raised: $5,000,000
Catena Biosciences

Berkeley, California, United States

Catena Biosciences is a biotechnology company that offers protein conjugation, building biologic structures, and medical research.

BiotechnologyLife Science
SeedMay 10, 2024
Amount Raised: $2,350,000