National Science Foundation logo

National Science Foundation

North America, Virginia, United States, Alexandria

Description

The National Science Foundation (NSF), through its America’s Seed Fund (SBIR/STTR) program, stands as a pivotal non-dilutive investor for deep technology and science-based startups in the United States. Unlike traditional venture capital firms, NSF's primary mission is to foster the translation of cutting-edge scientific and engineering research into commercial products and services, addressing national needs and promoting economic growth. They target high-risk, high-reward innovations that often struggle to secure early-stage private funding due to their long development cycles or unproven market potential.

NSF's funding mechanism is structured in phases. Phase I awards provide initial seed funding for proof-of-concept and feasibility studies, typically offering up to $275,000 for 6-12 months. Successful Phase I awardees can then apply for Phase II funding, which supports the research and development efforts towards commercialization, with awards typically reaching up to $1,000,000 over 24 months. This phased approach allows companies to de-risk their technology and build a solid foundation without relinquishing equity. The program is substantial, awarding nearly $200 million annually to startups and small businesses, as highlighted by the NSF's own description.

Beyond the significant non-dilutive capital, an NSF award provides substantial validation and prestige, often attracting follow-on private investment from venture capitalists and angel investors who view the rigorous peer-review process as a strong vetting mechanism. Companies also gain access to a network of mentors, business support resources, and government connections, further accelerating their path to market. The NSF's unique position as a government agency focused on foundational research ensures that its investments contribute to the nation's technological leadership and economic competitiveness, making it a highly sought-after funding source for innovative deep tech ventures.

Investor Profile

National Science Foundation has backed more than 4,101 startups, with 51 new investments in the last 12 months alone. The firm has led 3,918 rounds, about 96% of its total and boasts 214 exits across its portfolio.

Investment Focus Highlights

  • Concentrates on Grant, Seed, Pre Seed rounds (top funding stages).
  • Majority of deals are located in United States, Puerto Rico, United Kingdom.
  • Strong thematic focus on Health Care, Biotechnology, Manufacturing.
  • Led 47 rounds in the past year.
  • Typical check size: $275K – $1M.

Stage Focus

  • Grant (99%)
  • Seed (1%)

Country Focus

  • United States (99%)

Industry Focus

  • Health Care
  • Biotechnology
  • Manufacturing
  • Software
  • Medical
  • Information Technology
  • Medical Device
  • Education
  • Artificial Intelligence (Ai)
  • Electronics
circle-line
FAQ

Frequently Asked Questions

Learn who this investor regularly partners with—both firms and angels—and explore their latest activity.

Who does National Science Foundation frequently co-invest with?

Small Business Innovation Research
North America, Alabama, United States, America
Co-Investments: 6
National Institutes of Health
North America, Maryland, United States, Bethesda
Co-Investments: 9
MassChallenge
North America, Massachusetts, United States, Boston
Co-Investments: 4
VertueLab
North America, Oregon, United States, Portland
Co-Investments: 2
Keiretsu Capital
North America, Washington, United States, Seattle
Co-Investments: 2
Fusion Fund
North America, California, United States, Palo Alto
Co-Investments: 2
Lux Capital
North America, New York, United States, New York
Co-Investments: 2
Cleantech Open
North America, California, United States, Palo Alto
Co-Investments: 5
Alumni Ventures
North America, New Hampshire, United States, Manchester
Co-Investments: 3
US Department of Energy
North America, District of Columbia, United States, Washington
Co-Investments: 5

Which angels does National Science Foundation often collaborate with?

BL
North America, Massachusetts, United States, Boston
Shared Deals: 1
IJ
North America, California, United States, La Jolla
Shared Deals: 1
SV
North America, New Hampshire, United States, Salem
Shared Deals: 1
SL
North America, Pennsylvania, United States, Pittsburgh
Shared Deals: 1
SL
North America, Illinois, United States, Champaign
Shared Deals: 1

What are some of recent deals done by National Science Foundation?

Caravel Bio

Somerville, Massachusetts, United States

Engineering enzymes & enzyme carriers for sustainable catalysis

BiotechnologyChemicalManufacturing
GrantOct 16, 2025
Amount Raised: $7,800,000
Ioxus

Oneonta, New York, United States

Ioxus develops, manufactures and commercializes ultracapacitor technology for the military, transportation and alternative energy markets.

ElectronicsEnergyIndustrialManufacturing
GrantSep 25, 2025
Amount Raised: $100,000
Delta Bravo

Rock Hill, South Carolina, United States

Delta Bravo helps manufacturers turn data into Predictive Models that reduce downtime and waste while increasing quality and throughput.

AnalyticsArtificial Intelligence (AI)Information TechnologyMachine Learning
GrantSep 25, 2025
Amount Raised: $5,000,000
Hood College

Frederick, Maryland, United States

Hood College is a school in Frederick.

EducationHigher EducationOffice Administration
GrantSep 24, 2025
Amount Raised: $999,850
Akorn Technology

Berkeley, California, United States

Akorn uses upcycled, non-GMO corn by-products to manufacture edible coatings that make the shelf life of fresh produce last.

AgricultureAgTechFarmingFood ProcessingManufacturingSupply Chain ManagementSustainability
GrantSep 22, 2025
4Thought Technologies

New York, New York, United States

4Thought Technologies is an advanced no-code platform that unlocks the benefits of algorithmic trading and automated risk controls.

Financial ServicesTrading Platform
GrantSep 17, 2025
Amount Raised: $256,000
InnoTech Precision Medicine

Natick, Massachusetts, United States

InnoTech Precision goal is to transform disease diagnosis so that prompt and efficient treatment

Biotechnology
GrantSep 15, 2025
Amount Raised: $2,800,000
YOLO Immune

San Carlos, California, United States

YOLO Immune is creating precision immunotherapies to treat severe human illnesses.

GrantSep 13, 2025
Cascade Biocatalysts

Denver, Colorado, United States

Cascade Biocatalysts creates productive enzymes for economical biomanufacturing of sustainable chemicals.

BiotechnologyChemicalManufacturing
GrantSep 9, 2025
Amount Raised: $3,200,000
Yotta Labs

Seattle, Washington, United States

Building the GPU Cloud for efficient ML with heterogeneous hardware and cross-cloud orchestration

Artificial Intelligence (AI)Cloud ComputingGPU
GrantSep 8, 2025
Amount Raised: $300,000