National Science Foundation logo

National Science Foundation

North America, Virginia, United States, Alexandria

Description

The National Science Foundation (NSF), through its America’s Seed Fund (SBIR/STTR) program, stands as a pivotal non-dilutive investor for deep technology and science-based startups in the United States. Unlike traditional venture capital firms, NSF's primary mission is to foster the translation of cutting-edge scientific and engineering research into commercial products and services, addressing national needs and promoting economic growth. They target high-risk, high-reward innovations that often struggle to secure early-stage private funding due to their long development cycles or unproven market potential.

NSF's funding mechanism is structured in phases. Phase I awards provide initial seed funding for proof-of-concept and feasibility studies, typically offering up to $275,000 for 6-12 months. Successful Phase I awardees can then apply for Phase II funding, which supports the research and development efforts towards commercialization, with awards typically reaching up to $1,000,000 over 24 months. This phased approach allows companies to de-risk their technology and build a solid foundation without relinquishing equity. The program is substantial, awarding nearly $200 million annually to startups and small businesses, as highlighted by the NSF's own description.

Beyond the significant non-dilutive capital, an NSF award provides substantial validation and prestige, often attracting follow-on private investment from venture capitalists and angel investors who view the rigorous peer-review process as a strong vetting mechanism. Companies also gain access to a network of mentors, business support resources, and government connections, further accelerating their path to market. The NSF's unique position as a government agency focused on foundational research ensures that its investments contribute to the nation's technological leadership and economic competitiveness, making it a highly sought-after funding source for innovative deep tech ventures.

Investor Profile

National Science Foundation has backed more than 4,101 startups, with 51 new investments in the last 12 months alone. The firm has led 3,918 rounds, about 96% of its total and boasts 214 exits across its portfolio.

Investment Focus Highlights

  • Concentrates on Grant, Seed, Pre Seed rounds (top funding stages).
  • Majority of deals are located in United States, Puerto Rico, United Kingdom.
  • Strong thematic focus on Health Care, Biotechnology, Manufacturing.
  • Led 47 rounds in the past year.
  • Typical check size: $275K – $1M.

Stage Focus

  • Grant (99%)
  • Seed (1%)

Country Focus

  • United States (99%)

Industry Focus

  • Health Care
  • Biotechnology
  • Manufacturing
  • Software
  • Medical
  • Information Technology
  • Medical Device
  • Education
  • Artificial Intelligence (Ai)
  • Electronics
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FAQ

Frequently Asked Questions

Learn who this investor regularly partners with—both firms and angels—and explore their latest activity.

Who does National Science Foundation frequently co-invest with?

Small Business Innovation Research
North America, Alabama, United States, America
Co-Investments: 6
National Institutes of Health
North America, Maryland, United States, Bethesda
Co-Investments: 9
MassChallenge
North America, Massachusetts, United States, Boston
Co-Investments: 4
VertueLab
North America, Oregon, United States, Portland
Co-Investments: 2
Keiretsu Capital
North America, Washington, United States, Seattle
Co-Investments: 2
Fusion Fund
North America, California, United States, Palo Alto
Co-Investments: 2
Lux Capital
North America, New York, United States, New York
Co-Investments: 2
Cleantech Open
North America, California, United States, Palo Alto
Co-Investments: 5
Alumni Ventures
North America, New Hampshire, United States, Manchester
Co-Investments: 3
US Department of Energy
North America, District of Columbia, United States, Washington
Co-Investments: 5

Which angels does National Science Foundation often collaborate with?

BL
North America, Massachusetts, United States, Boston
Shared Deals: 1
IJ
North America, California, United States, La Jolla
Shared Deals: 1
SV
North America, New Hampshire, United States, Salem
Shared Deals: 1
SL
North America, Pennsylvania, United States, Pittsburgh
Shared Deals: 1
SL
North America, Illinois, United States, Champaign
Shared Deals: 1

What are some of recent deals done by National Science Foundation?

Current

Chicago, Illinois, United States

Current is a Chicago-based nonprofit hub accelerating water tech innovation and commercialization in the Great Lakes region.

SustainabilityWater
GrantMar 30, 2026
Amount Raised: $45,000,000
Future Use of Energy in Louisiana

Louisiana, Missouri, United States

Future Use of Energy in Louisiana is a nonprofit organization that researches and develops energy and hydrocarbon products.

EnergyFuelNon Profit
GrantMar 24, 2026
Amount Raised: $45,000,000
Computer Science Teachers Association

Chicago, Illinois, United States

CSTA supports and promotes the teaching of computer science and other computing disciplines.

Association
GrantMar 19, 2026
Amount Raised: $11,000,000
University of Oklahoma

Norman, Oklahoma, United States

University of Oklahoma is a public research university that provides variety of undergraduate and graduate programs in multiple fields.

EducationHigher EducationUniversities
GrantMar 12, 2026
Amount Raised: $1,000,000
Arkansas Tech University

Russellville, Arkansas, United States

Arkansas Tech University is a school in Russellville.

EdTechEducationTraining
GrantFeb 26, 2026
Amount Raised: $2,000,000
Morehouse College

Atlanta, Georgia, United States

Morehouse College operates as a historic, all-male, private liberal arts institution.

College RecruitingEducationPerforming Arts
GrantFeb 24, 2026
Amount Raised: $5,000,000
Northwest Nazarene University

Nampa, Idaho, United States

Northwest Nazarene University is higher learning institution that focuses on the liberal arts.

GrantFeb 23, 2026
Amount Raised: $150,000
The University of Texas at Dallas

Richardson, Texas, United States

The University of Texas at Dallas offers academic programs across its eight schools and hosts more than 50 research centers and institutes.

EducationHigher EducationUniversities
GrantDec 29, 2025
Amount Raised: $250,000
University of Massachusetts, Lowell

Lowell, Massachusetts, United States

University of Massachusetts, Lowell is a school in Lowell.

EdTechEducationMarket ResearchUniversities
GrantDec 29, 2025
Amount Raised: $250,000
US Ignite

Washington, District of Columbia, United States

US Ignite develops next-generation apps that help developers, communities, and individuals that provide transformative public benefit.

App DiscoveryAssociationCommunitiesNon Profit
GrantDec 17, 2025
Amount Raised: $3,900,000

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