National Science Foundation logo

National Science Foundation

North America, Virginia, United States, Alexandria

Description

The National Science Foundation (NSF), through its America’s Seed Fund (SBIR/STTR) program, stands as a pivotal non-dilutive investor for deep technology and science-based startups in the United States. Unlike traditional venture capital firms, NSF's primary mission is to foster the translation of cutting-edge scientific and engineering research into commercial products and services, addressing national needs and promoting economic growth. They target high-risk, high-reward innovations that often struggle to secure early-stage private funding due to their long development cycles or unproven market potential.

NSF's funding mechanism is structured in phases. Phase I awards provide initial seed funding for proof-of-concept and feasibility studies, typically offering up to $275,000 for 6-12 months. Successful Phase I awardees can then apply for Phase II funding, which supports the research and development efforts towards commercialization, with awards typically reaching up to $1,000,000 over 24 months. This phased approach allows companies to de-risk their technology and build a solid foundation without relinquishing equity. The program is substantial, awarding nearly $200 million annually to startups and small businesses, as highlighted by the NSF's own description.

Beyond the significant non-dilutive capital, an NSF award provides substantial validation and prestige, often attracting follow-on private investment from venture capitalists and angel investors who view the rigorous peer-review process as a strong vetting mechanism. Companies also gain access to a network of mentors, business support resources, and government connections, further accelerating their path to market. The NSF's unique position as a government agency focused on foundational research ensures that its investments contribute to the nation's technological leadership and economic competitiveness, making it a highly sought-after funding source for innovative deep tech ventures.

Investor Profile

National Science Foundation has backed more than 4,101 startups, with 51 new investments in the last 12 months alone. The firm has led 3,918 rounds, about 96% of its total and boasts 214 exits across its portfolio.

Investment Focus Highlights

  • Concentrates on Grant, Seed, Pre Seed rounds (top funding stages).
  • Majority of deals are located in United States, Puerto Rico, United Kingdom.
  • Strong thematic focus on Health Care, Biotechnology, Manufacturing.
  • Led 47 rounds in the past year.
  • Typical check size: $275K – $1M.

Stage Focus

  • Grant (99%)
  • Seed (1%)

Country Focus

  • United States (99%)

Industry Focus

  • Health Care
  • Biotechnology
  • Manufacturing
  • Software
  • Medical
  • Information Technology
  • Medical Device
  • Education
  • Artificial Intelligence (Ai)
  • Electronics
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FAQ

Frequently Asked Questions

Learn who this investor regularly partners with—both firms and angels—and explore their latest activity.

Who does National Science Foundation frequently co-invest with?

Small Business Innovation Research
North America, Alabama, United States, America
Co-Investments: 6
National Institutes of Health
North America, Maryland, United States, Bethesda
Co-Investments: 9
MassChallenge
North America, Massachusetts, United States, Boston
Co-Investments: 4
VertueLab
North America, Oregon, United States, Portland
Co-Investments: 2
Keiretsu Capital
North America, Washington, United States, Seattle
Co-Investments: 2
Fusion Fund
North America, California, United States, Palo Alto
Co-Investments: 2
Lux Capital
North America, New York, United States, New York
Co-Investments: 2
Cleantech Open
North America, California, United States, Palo Alto
Co-Investments: 5
Alumni Ventures
North America, New Hampshire, United States, Manchester
Co-Investments: 3
US Department of Energy
North America, District of Columbia, United States, Washington
Co-Investments: 5

Which angels does National Science Foundation often collaborate with?

BL
North America, Massachusetts, United States, Boston
Shared Deals: 1
IJ
North America, California, United States, La Jolla
Shared Deals: 1
SV
North America, New Hampshire, United States, Salem
Shared Deals: 1
SL
North America, Pennsylvania, United States, Pittsburgh
Shared Deals: 1
SL
North America, Illinois, United States, Champaign
Shared Deals: 1

What are some of recent deals done by National Science Foundation?

Worcester Polytechnic Institute

Worcester, Massachusetts, United States

WPI is a private technological university that offers research facilities and a community of students and members.

CommunitiesEducationHigher EducationSTEM Education
GrantJul 25, 2025
Amount Raised: $396,000
Arkansas Research Alliance

Conway, Arkansas, United States

Arkansas Research Alliance provides research in drug development and cutting edge membrane technology.

ConsultingMarket ResearchNon ProfitRecruiting
GrantJul 21, 2025
Amount Raised: $8,000,000
gotLearning

Bryn Mawr, Pennsylvania, United States

gotLearning is the creator of LearningPulse and gotFeedback. We help educators in K12 and HE manage qualitative evidence overload.

EdTechEducationHigher Education
GrantJul 15, 2025
Amount Raised: $1,250,000
University of Vermont

Burlington, Vermont, United States

University of Vermont is a public university that provides undergraduate, graduate, and professional degree programs.

E-LearningEducationHealth CareUniversities
GrantJul 15, 2025
Amount Raised: $5,500,000
CPR Therapeutics

Putney, Vermont, United States

CPR Therapeutics is a medical device company developing the next-generation system for cardiopulmonary resuscitation.

Health CareMedicalMedical Device
GrantJul 15, 2025
Amount Raised: $1,200,000
Georgia Tech Research

Atlanta, Georgia, United States

Georgia Tech Research is shaping the future of basic and applied research by pursuing inventive solutions to pressing problems.

EducationNews
GrantJul 15, 2025
Amount Raised: $20,000,000
Beamlink

Los Angeles, California, United States

What if cell towers were designed in the 2020s, not the 90s?

HardwareSoftwareTelecommunications
GrantJul 14, 2025
Amount Raised: $190,715
Spearhead Bio

St Louis, Missouri, United States

Spearhead Bio pioneers in native genome engineering, enabling precision agricultural trait integration.

AgricultureAgTechBiotechnology
GrantJul 14, 2025
Amount Raised: $305,000
University of Rhode Island

Kingston, Rhode Island, United States

University of Rhode Island is a research and graduate institution offering graduate and undergraduate programs.

EducationHealth CareUniversities
GrantJul 8, 2025
Amount Raised: $7,000,000
Elementium Materials

Katy, Texas, United States

Elementium is a battery materials company that develops and scales novel electrolyte formulations for advanced lithium-ion chemistries.

BatteryEnergy StorageRenewable Energy
GrantJul 2, 2025
Amount Raised: $100,000