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OSF Ventures

North America, Illinois, United States, Peoria

Description

OSF Ventures is the corporate venture capital arm of OSF HealthCare, a leading integrated health system based in Peoria, Illinois. Established with a strategic imperative, the firm focuses on investing in innovative healthcare technology, digital health, medical devices, and diagnostics that align with OSF HealthCare's mission to transform patient care and improve operational efficiencies. Their investment strategy is deeply rooted in identifying solutions that can be integrated into clinical practice, offering a unique value proposition to portfolio companies beyond just capital.

The firm primarily targets early to growth-stage companies, often participating in Series A and B rounds. OSF Ventures seeks out technologies and solutions that address critical challenges within the healthcare ecosystem, including enhancing patient experience, improving clinical outcomes, reducing costs, and expanding access to care. Their strategic alignment allows them to provide portfolio companies with invaluable access to OSF HealthCare's extensive clinical expertise, real-world testing environments, and potential for rapid adoption within a large health system.

OSF Ventures has demonstrated a strong commitment to fostering innovation, evidenced by the successful closing of its third fund, OSF Ventures III, at $100 million in 2021. This substantial fund enables them to continue their impactful investments in the evolving healthcare landscape. Typically, their initial investment check sizes range from $500,000 to $5 million, though they often participate in larger syndicated rounds. This approach underscores their role as a strategic partner, not just a financial one, aiming to accelerate the development and adoption of groundbreaking healthcare solutions.

Investor Profile

OSF Ventures has backed more than 31 startups, with 3 new investments in the last 12 months alone. The firm has led 6 rounds, about 19% of its total and boasts 8 exits across its portfolio.

Investment Focus Highlights

  • Concentrates on Series B, Series A, Series C rounds (top funding stages).
  • Majority of deals are located in United States, Israel.
  • Strong thematic focus on Health Care, Medical, Medical Device.
  • Typical check size: $500K – $5M.

Stage Focus

  • Series B (29%)
  • Series A (23%)
  • Series C (16%)
  • Series Unknown (16%)
  • Series D (6%)
  • Seed (3%)
  • Corporate Round (3%)
  • Series E (3%)

Country Focus

  • United States (97%)
  • Israel (3%)

Industry Focus

  • Health Care
  • Medical
  • Medical Device
  • Health Diagnostics
  • Machine Learning
  • Artificial Intelligence (Ai)
  • Hospital
  • Information Technology
  • Biotechnology
  • Mental Health
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FAQ

Frequently Asked Questions

Learn who this investor regularly partners with—both firms and angels—and explore their latest activity.

Who does OSF Ventures frequently co-invest with?

SV Health Investors
North America, Massachusetts, United States, Boston
Co-Investments: 2
HealthX Ventures
North America, Wisconsin, United States, Madison
Co-Investments: 2
Lumira Ventures
North America, Ontario, Canada, Toronto
Co-Investments: 2
Wanxiang America Healthcare Investments Group
North America, Illinois, United States, Illinois City
Co-Investments: 2
Bioventures Investors
North America, Massachusetts, United States, Wellesley
Co-Investments: 2
UnityPoint Health Ventures
North America, Iowa, United States, West Des Moines
Co-Investments: 3
Ascension Ventures
North America, Missouri, United States, Clarkton
Co-Investments: 3
Aperture Venture Partners
North America, New York, United States, New York
Co-Investments: 3
Sony Innovation Fund
Asia, Tokyo, Japan, Tokyo
Co-Investments: 2
LRVHealth
North America, Massachusetts, United States, Boston
Co-Investments: 3

What are some of recent deals done by OSF Ventures?

hellocare

Clearwater, Florida, United States

hellocare is an end-to-end telehealth and virtual healthcare delivery platform comprising software, hardware, and AI.

Artificial Intelligence (AI)Health CareInformation TechnologyPrivate Social NetworkingSocial MediaSoftware
Series UnknownApr 15, 2025
Amount Raised: $47,000,000
Cala Health

San Mateo, California, United States

Cala Health is a bioelectronic medicine company that develops wearable neuromodulation devices for the treatment of chronic diseases.

Health CareMedicalMedical DeviceWearables
Series CDec 9, 2024
Amount Raised: $50,000,000
ShiraTronics

Minneapolis, Minnesota, United States

ShiraTronics develops neuromodulation technology to combat debilitating chronic migraine.

Clinical TrialsHealth CareMedical Device
Series BSep 30, 2024
Amount Raised: $66,000,000
Huddle Up

Madison, Wisconsin, United States

Huddle Up specializes in providing speech therapy, occupational therapy, and mental health services.

E-LearningFitnessHealth CareHospitalMental HealthSpeech Recognition
Series CApr 10, 2024
Cardiosense

Chicago, Illinois, United States

Cardiosense is a digital biomarker platform that provides multi-sensor devices and proprietary algorithms to detect early signs of diseases.

Artificial Intelligence (AI)Health CareMachine LearningPredictive AnalyticsWearables
Series ADec 8, 2022
Amount Raised: $15,100,000
410 Medical

Durham, North Carolina, United States

410 Medical is a medical device company dedicated to developing innovative products that enable frontline medical providers to improve care.

Health CareMedicalMedical Device
Series BNov 10, 2022
Amount Raised: $6,300,000
Digital Diagnostics

Coralville, Iowa, United States

Digital Diagnostics is an AI diagnostics company that transforms the quality, accessibility, and affordability of healthcare.

Artificial Intelligence (AI)Health CareHealth DiagnosticsMachine LearningMedical Device
Series BAug 23, 2022
Amount Raised: $75,000,000
CancerIQ

Chicago, Illinois, United States

CancerIQ provides a precision prevention platform that empowers community-based providers to prevent cancer.

Health CareInformation TechnologyMedical
Series BMar 3, 2022
Amount Raised: $14,000,000
Epitel

Salt Lake City, Utah, United States

Epitel is empowering clinicians, patients, and caregivers who live with or care for neurological disorders with wearables and powerful AI.

Emergency MedicineHealth CareHealth DiagnosticsHome Health CareHospitalMedicalMedical DevicemHealthNeuroscience
Series AFeb 16, 2022
Amount Raised: $12,500,000
TailorMed

Tel Aviv, Tel Aviv, Israel

Reinventing financial navigation

Financial ServicesFinTechFitnessHealth CareMachine LearningWellness
Series UnknownSep 29, 2021
Amount Raised: $5,000,000