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Shangbay Capital

North America, California, United States, Palo Alto

Description

Shangbay Capital is a Palo Alto-based venture capital firm with a specialized focus on early-stage investments within the life sciences sector. Founded by Dr. Lihuai Zhao, the firm primarily targets companies innovating in medical devices, biotechnology, and mobile healthcare. A distinctive aspect of Shangbay Capital's strategy is its emphasis on cross-border opportunities, effectively bridging cutting-edge U.S. technologies with the expansive market potential in China.

The firm's investment approach is centered on identifying disruptive technologies and promising ventures at their nascent stages, typically participating in Seed, Series A, and Series B funding rounds. Shangbay Capital leverages its profound industry expertise and extensive network to offer not only financial capital but also strategic guidance and operational support to its portfolio companies. Their goal is to accelerate the growth and market penetration of healthcare innovations, particularly those with global applicability and a strong potential for impact.

Shangbay Capital has demonstrated a significant commitment to the life sciences space through substantial capital deployment. The firm has successfully raised multiple funds, including Shangbay Capital Fund I, which secured $100 million, and Shangbay Capital Fund II, which raised $150 million, bringing their total assets under management to approximately $250 million. With over 30 investments to date, Shangbay plays a crucial role in fostering the development of next-generation healthcare solutions, frequently acting as a lead investor in early-stage financing rounds. Their typical initial investment for early-stage companies ranges from $1 million to $10 million, reflecting their commitment to providing meaningful support for promising ventures.

Investor Profile

Shangbay Capital has backed more than 41 startups, with 4 new investments in the last 12 months alone. The firm has led 11 rounds, about 27% of its total and boasts 2 exits across its portfolio.

Investment Focus Highlights

  • Concentrates on Series A, Series B, Series Unknown rounds (top funding stages).
  • Majority of deals are located in United States, Canada, China.
  • Strong thematic focus on Health Care, Medical Device, Medical.
  • Typical check size: $1M – $10M.

Stage Focus

  • Series A (41%)
  • Series B (24%)
  • Series Unknown (10%)
  • Series D (7%)
  • Series C (7%)
  • Seed (5%)
  • Series E (2%)
  • Private Equity (2%)

Country Focus

  • United States (93%)
  • Canada (5%)
  • China (2%)

Industry Focus

  • Health Care
  • Medical Device
  • Medical
  • Biotechnology
  • Therapeutics
  • Biopharma
  • Health Diagnostics
  • Genetics
  • Neuroscience
  • Artificial Intelligence (Ai)
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FAQ

Frequently Asked Questions

Learn who this investor regularly partners with—both firms and angels—and explore their latest activity.

Who does Shangbay Capital frequently co-invest with?

CA
North America, Massachusetts, United States, Boston
Co-Investments: 2
Co-Investments: 4
UpHonest Capital
North America, California, United States, Palo Alto
Co-Investments: 2
MBX Capital
North America, New York, United States, New York
Co-Investments: 2
Graphene Ventures
North America, California, United States, Palo Alto
Co-Investments: 2
HongShan
Asia, Beijing, China, Beijing
Co-Investments: 2
Metaplanet
Europe, Harjumaa, Estonia, Tallinn
Co-Investments: 2
SV Tech Ventures
North America, California, United States, Palo Alto
Co-Investments: 4
Action Potential Venture Capital
North America, Massachusetts, United States, Cambridge
Co-Investments: 3
Invus
North America, New York, United States, New York
Co-Investments: 2

Which angels does Shangbay Capital often collaborate with?

PD
North America, Georgia, United States, Atlanta
Shared Deals: 1
JW
North America, Virginia, United States, Charlottesville
Shared Deals: 1
PL
North America, California, United States, Palo Alto
Shared Deals: 1
KR
Asia, Maharashtra, India, Mumbai
Shared Deals: 1
MW
Europe, Stockholms Lan, Sweden, Stockholm
Shared Deals: 1
Adrian Cheng
Asia, Hong Kong
Shared Deals: 1

What are some of recent deals done by Shangbay Capital?

Evident Vascular

San Jose, California, United States

Evident Vascular offers an advanced IVUS platform that leverages Artificial Intelligence to deliver superior Vascular.

Artificial Intelligence (AI)Health CareMedicalMedical Device
Series BMar 25, 2025
Fluid Biomed

Calgary, Alberta, Canada

Fluid Biomed is a clinical stage medical device company that develops polymer-based brain stent to cure aneurysms.

Health CareMedicalMedical Device
Series ADec 16, 2024
Amount Raised: $27,000,000
Inquis Medical

Redwood City, California, United States

Inquis Medical is developing thrombectomy technology, enabling an efficient single-pass thrombectomy with minimal blood loss.

Health CareMedical
Series BNov 4, 2024
Amount Raised: $40,000,000
Venova Medical

Los Gatos, California, United States

Venova Medical develops vascular access systems for patients requiring renal replacement therapy.

Health CareMedicalMedical DeviceTherapeutics
Series BSep 4, 2024
Amount Raised: $30,000,000
Avation Medical

Columbus, Ohio, United States

Avation Medical is pioneering new platforms for wearable nerve stimulation systems.

Health CareMedicalMedical DeviceMobile DevicesNeuroscienceWearables
Series CFeb 1, 2024
Amount Raised: $22,000,000
Laplace Interventional

Plymouth, Minnesota, United States

Laplace is a medical device company that develops transcatheter tricuspid valve technology.

Health CareMedicalMedical Device
Series BJul 24, 2023
Amount Raised: $12,900,000
Luminopia

Cambridge, Massachusetts, United States

Luminopia develops a new class of treatments for significant neuro-visual disorders.

Health CareMedicalVirtual Reality
Series AJun 27, 2023
Amount Raised: $16,000,000
Presidio Medical

South San Francisco, California, United States

Presidio Medical is a medtech company that develops a transformational neuromodulation platform.

Developer PlatformInformation TechnologyMedicalSoftware
Series CJun 26, 2023
Amount Raised: $72,000,000
Solenic Medical

College Station, Texas, United States

Solenic Medical is a medical device company that develops a non-invasive treatment for infected metallic implants in the body.

BiotechnologyHealth CareMedicalMedical Device
Series AJun 20, 2023
Amount Raised: $5,100,000
Noah Medical

San Carlos, California, United States

Noah Medical develops medical robotics using its next-generation robotic platform for patient diagnosis and treatment.

Health CareHealth DiagnosticsMedical Device
Series BApr 19, 2023
Amount Raised: $150,000,000