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The Blue Venture Fund

North America, Illinois, United States, Chicago

Description

The Blue Venture Fund is the strategic venture capital arm of the Blue Cross Blue Shield Association (BCBSA), a federation of 34 independent Blue Cross and Blue Shield companies. Established with a clear mandate to foster innovation and improve healthcare outcomes, the fund strategically invests in promising companies that align with the evolving needs of the healthcare system. Its primary objective is to identify and support solutions that can enhance the quality, affordability, and accessibility of care for the millions of members served by the Blue Cross and Blue Shield plans across the United States. This strategic alignment allows the fund to not only provide capital but also facilitate valuable partnerships and market access for its portfolio companies.

The fund's investment thesis centers on key areas poised to transform healthcare, including digital health, care delivery innovation, health equity, and data analytics. It typically targets early to growth-stage companies, participating in Seed, Series A, and Series B rounds, though it may engage in later stages for compelling opportunities. Beyond financial investment, The Blue Venture Fund acts as a strategic partner, leveraging the extensive network and deep industry expertise of the BCBSA system. This unique position enables portfolio companies to gain insights, pilot programs, and potentially scale their solutions across a vast and diverse patient population, accelerating their growth and market penetration.

With a significant capital base, including a reported fund size of $600 million as of 2022, The Blue Venture Fund has established itself as a notable player in the healthcare venture landscape. Since its inception, it has made investments in over 70 companies, demonstrating a consistent commitment to its strategic mission. The fund's typical first check sizes for early to growth-stage investments generally range from $2 million for promising seed or early Series A rounds, extending up to $15 million for more mature Series A or B opportunities. This flexibility allows them to engage with a broad spectrum of innovative healthcare startups, from nascent technologies to more established solutions seeking to scale.

The Blue Venture Fund's approach emphasizes long-term partnerships, aiming to integrate innovative solutions into the broader Blue Cross and Blue Shield ecosystem. Its strategic focus ensures that investments are not merely financial but are deeply rooted in the potential to deliver tangible improvements to healthcare delivery and member experience, reinforcing the BCBSA's commitment to leading healthcare transformation.

Investor Profile

The Blue Venture Fund has backed more than 101 startups, with 3 new investments in the last 12 months alone. The firm has led 36 rounds, about 36% of its total and boasts 22 exits across its portfolio.

Investment Focus Highlights

  • Concentrates on Series A, Series B, Series C rounds (top funding stages).
  • Majority of deals are located in United States, United Kingdom, India.
  • Strong thematic focus on Health Care, Medical, Wellness.
  • Led 1 rounds in the past year.
  • Typical check size: $2M – $15M.

Stage Focus

  • Series A (31%)
  • Series B (20%)
  • Series C (12%)
  • Seed (12%)
  • Series Unknown (8%)
  • Private Equity (7%)
  • Series D (5%)
  • Series E (2%)
  • Post Ipo Equity (1%)
  • Series H (1%)

Country Focus

  • United States (95%)
  • United Kingdom (3%)
  • India (2%)

Industry Focus

  • Health Care
  • Medical
  • Wellness
  • Software
  • Hospital
  • Information Technology
  • Health Diagnostics
  • Biotechnology
  • Artificial Intelligence (Ai)
  • Fitness
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FAQ

Frequently Asked Questions

Learn who this investor regularly partners with—both firms and angels—and explore their latest activity.

Who does The Blue Venture Fund frequently co-invest with?

HCA
North America, Tennessee, United States, Nashville
Co-Investments: 6
.406 Ventures
North America, Massachusetts, United States, Boston
Co-Investments: 8
Healthbox
North America, Illinois, United States, Chicago
Co-Investments: 6
Sandbox Industries
North America, Illinois, United States, Chicago
Co-Investments: 41
Echo Health Ventures
North America, Washington, United States, Seattle
Co-Investments: 5
Noro-Moseley Partners
North America, Georgia, United States, Atlanta
Co-Investments: 6
Camden Partners
North America, Maryland, United States, Baltimore
Co-Investments: 4
LRVHealth
North America, Massachusetts, United States, Boston
Co-Investments: 5
Section 32
North America, California, United States, San Diego
Co-Investments: 4
HLM Venture Partners
North America, Massachusetts, United States, Boston
Co-Investments: 6

Which angels does The Blue Venture Fund often collaborate with?

PK
North America, Tennessee, United States, Nashville
Shared Deals: 1
BD
North America, Kentucky, United States, Louisville
Shared Deals: 1
JF
North America, Maryland, United States, Baltimore
Shared Deals: 1
TF
North America, Texas, United States, Dallas
Shared Deals: 1
BL
North America, California, United States, Menlo Park
Shared Deals: 1
BG
North America, Texas, United States, Austin
Shared Deals: 1
AK
North America, Pennsylvania, United States, Philadelphia
Shared Deals: 1
SZ
North America, New York, United States, New York
Shared Deals: 1
AP
North America, New York, United States, New York
Shared Deals: 2
RD
North America, Georgia, United States, Atlanta
Shared Deals: 1

What are some of recent deals done by The Blue Venture Fund?

Ultromics

Oxford, Oxfordshire, United Kingdom

Ultromics develops AI-driven cardiology solutions to assist in cardiovascular disease diagnosis through echocardiography.

Artificial Intelligence (AI)Health CareHealth DiagnosticsMedicalSoftware
Series CJul 31, 2025
Amount Raised: $55,000,000
PinkDx

Indianapolis, Indiana, United States

PinkDx is a biotechnology company.

BiopharmaBiotechnology
Series AJan 23, 2025
Amount Raised: $5,000,000
Upward Health

Hauppauge, New York, United States

Upward Health is a home-based medical group specializing in primary medical and behavioral care for individuals with complex needs.

Health CareMedicalService Industry
Series CJan 16, 2025
Fort Health

New York, New York, United States

Fort Health offers a solution that provides mental health care for families.

Health CareMedicalMental HealthWellness
SeedNov 12, 2024
Amount Raised: $5,500,000
Humata Health

Winter Park, Florida, United States

Humata Health is an AI-enabled deep clinical integration that creates prior authorizations for payers and providers using AI and automation.

Artificial Intelligence (AI)
Series AJun 20, 2024
Amount Raised: $25,000,000
Tuesday Health

Nashville, Tennessee, United States

Tuesday Health empowers lives through supportive care by easing the symptoms and stress of serious illness.

Health CareHospitalWellness
Series AMay 21, 2024
Amount Raised: $60,000,000
Sempre Health

San Francisco, California, United States

Sempre Health is a platform that brings behavior-based, dynamic pricing to healthcare.

Health CareHospitalMedical
Series CSep 13, 2023
Amount Raised: $20,000,000
Octave

Menlo Park, California, United States

Octave is a biotechnology company that uses precision medicine and scientific insights to treat patients with multiple sclerosis.

BiotechnologyClinical TrialsHealth CareHealth DiagnosticsMedicalPrecision Medicine
Series BJul 26, 2023
Amount Raised: $32,500,070
Nest Health

New Orleans, Louisiana, United States

Nest Health offers medical services that aim to minimize the stress of arranging childcare, making travel arrangements, and leaving home.

Child CareMedicalWellness
SeedMar 23, 2023
Amount Raised: $15,000,000
Onc.AI

San Carlos, California, United States

Onc.AI is a software that specializes in clinical oncology, genomics, proteomics, and radiomics.

BiotechnologyHealth DiagnosticsMedicalOncologySoftware
Series AJan 5, 2023
Amount Raised: $25,000,000