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Vertex Ventures HC

North America, California, United States, Palo Alto

Description

Vertex Ventures HC is a dedicated healthcare venture capital fund based in Palo Alto, United States, specializing in early-stage and growth-stage investments across the biopharmaceutical, medical device, and digital health sectors. As part of the broader Vertex Holdings global network, the firm leverages an extensive international presence and deep industry expertise to identify and nurture transformative healthcare companies. Their strategic focus is on innovative solutions that address significant unmet medical needs and improve patient outcomes.

The firm's investment strategy centers on providing capital and strategic support to companies from Series A through Series C rounds. Vertex Ventures HC is known for its hands-on approach, working closely with portfolio companies to accelerate their development, navigate regulatory pathways, and scale their operations. A significant milestone for the firm was the closing of its second fund, Vertex Ventures HC Fund II, in 2021, which secured $200 million in commitments. This followed their successful first fund, Vertex Ventures HC Fund I, which closed at $150 million in 2018, demonstrating their growing capacity and commitment to the healthcare innovation ecosystem.

While specific check sizes can vary depending on the stage and needs of the portfolio company, Vertex Ventures HC typically deploys initial investments ranging from $5 million to $20 million. This range allows them to lead or co-lead Series A rounds, where they often provide significant capital and strategic guidance, as well as participate meaningfully in larger Series B and C rounds. The firm seeks out companies with strong scientific foundations, experienced management teams, and clear pathways to market, aiming to build long-term partnerships that drive substantial value creation in the healthcare industry.

Investor Profile

Vertex Ventures HC has backed more than 42 startups, with 4 new investments in the last 12 months alone. The firm has led 3 rounds, about 7% of its total and boasts 9 exits across its portfolio.

Investment Focus Highlights

  • Concentrates on Series B, Series C, Series A rounds (top funding stages).
  • Majority of deals are located in United States, United Kingdom, Switzerland.
  • Strong thematic focus on Biotechnology, Health Care, Medical.
  • Typical check size: $5M – $20M.

Stage Focus

  • Series B (31%)
  • Series C (24%)
  • Series A (24%)
  • Series D (14%)
  • Series E (2%)
  • Debt Financing (2%)
  • Series Unknown (2%)

Country Focus

  • United States (93%)
  • United Kingdom (2%)
  • Switzerland (2%)
  • China (2%)

Industry Focus

  • Biotechnology
  • Health Care
  • Medical
  • Therapeutics
  • Medical Device
  • Pharmaceutical
  • Biopharma
  • Life Science
  • Clinical Trials
  • Oncology
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FAQ

Frequently Asked Questions

Learn who this investor regularly partners with—both firms and angels—and explore their latest activity.

Who does Vertex Ventures HC frequently co-invest with?

Alexandria Venture Investments
North America, California, United States, Pasadena
Co-Investments: 9
Samsara BioCapital
North America, California, United States, Palo Alto
Co-Investments: 6
New Enterprise Associates
North America, California, United States, Menlo Park
Co-Investments: 10
RA Capital Management
North America, Massachusetts, United States, Boston
Co-Investments: 8
Vertex Ventures
Asia, Central Region, Singapore, Singapore
Co-Investments: 18
Lightstone Ventures
North America, California, United States, Menlo Park
Co-Investments: 5
Morgenthaler Ventures
North America, California, United States, Menlo Park
Co-Investments: 7
Windham Venture Partners
North America, New York, United States, New York
Co-Investments: 7
Aisling Capital
North America, New York, United States, New York
Co-Investments: 5
ARCH Venture Partners
North America, Illinois, United States, Chicago
Co-Investments: 6

Which angels does Vertex Ventures HC often collaborate with?

Shared Deals: 1

What are some of recent deals done by Vertex Ventures HC?

Allay Therapeutics

San Jose, California, United States

Allay Therapeutics offers analgesic products for post-surgical pain management and recuperation.

BiotechnologyHealth CareMedicalTherapeutics
Series DJun 5, 2025
Amount Raised: $57,500,000
Spyglass Pharma

Aliso Viejo, California, United States

Spyglass Pharma provides medicine for ophthalmic diseases.

DeliveryMedicalPharmaceutical
Series DJun 2, 2025
Amount Raised: $75,000,000
Indapta Therapeutics

San Francisco, California, United States

Indapta Therapeutics is a privately held biotechnology company.

BiopharmaBiotechnologyMedical
Series UnknownDec 17, 2024
Amount Raised: $22,500,000
Moximed

Hayward, California, United States

Moximed develops innovative therapies for patients with knee osteoarthritis.

BiotechnologyHealth CareMedical Device
Series DAug 13, 2024
Amount Raised: $61,000,000
NeuSpera Medical

San Jose, California, United States

NeuSpera Medical is a manufacturing firm that designs, manufactures, and sells implantable neuromodulation medical devices.

Machinery ManufacturingMedical DeviceProduct Design
Series DJul 15, 2024
Amount Raised: $23,000,000
TORL BioTherapeutics

Culver City, California, United States

TORL BioTherapeutics is a clinical-stage biopharmaceutical business.

BiopharmaBiotechnologyClinical Trials
Series BApr 10, 2024
Amount Raised: $158,000,000
Eyebiotech

New York, New York, United States

Eyebiotech is an ophthalmology biotechnology company that specializes in therapies for eye diseases.

BiotechnologyMedical
Series ANov 14, 2023
Amount Raised: $65,000,000
Septerna

San Francisco, California, United States

Septerna is a biotech firm unlocking diverse drug discovery potential in G protein-coupled receptors across various diseases.

BiotechnologyInformation TechnologyMedicalSoftware
Series BJul 11, 2023
Amount Raised: $150,000,000
Spyglass Pharma

Aliso Viejo, California, United States

Spyglass Pharma provides medicine for ophthalmic diseases.

DeliveryMedicalPharmaceutical
Series CJul 10, 2023
Amount Raised: $90,000,000
Boundless Bio

La Jolla, California, United States

Boundless Bio is a precision oncology company that develops therapeutics directed against extrachromosomal DNA in aggressive cancers.

BiotechnologyHealth CareLife ScienceOncologyTherapeutics
Series CMay 16, 2023
Amount Raised: $100,000,000