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Polychain

North America, California, United States, San Francisco

Description

Polychain Capital, based in San Francisco, California, stands as a pioneering and influential venture capital firm singularly focused on the cryptocurrency and blockchain sectors. Founded in 2016 by Olaf Carlson-Wee, Coinbase's first employee, Polychain quickly established itself as one of the earliest and largest dedicated crypto investment funds. Its investment thesis centers on identifying and backing foundational protocols and disruptive applications that leverage decentralized technologies, aiming to shape the future of Web3.

The firm employs a long-term, conviction-driven investment strategy, often taking significant stakes in early-stage projects, from seed to Series A and beyond. Polychain is known for its deep technical due diligence and its willingness to support projects through multiple funding rounds, often playing an active role in governance and ecosystem development. Over the years, Polychain has raised substantial capital, including a reported $400 million for its Polychain Ventures III fund in 2021, demonstrating its significant capital deployment capabilities. Its portfolio boasts a roster of industry giants, including early investments in protocols like Polkadot, Dfinity, and Avalanche, alongside decentralized finance (DeFi) innovators such as Uniswap and Compound.

Polychain's impact extends beyond capital provision; it acts as a strategic partner, leveraging its extensive network and expertise to guide portfolio companies. The firm's philosophy is rooted in a belief in the transformative potential of decentralized networks to redefine digital ownership, finance, and global coordination. While specific check sizes can vary based on the project's stage and capital requirements, Polychain typically deploys significant first checks, often ranging from $2 million for promising seed-stage ventures up to $25 million for leading Series A rounds. This substantial financial backing, combined with their strategic guidance, positions Polychain Capital as a formidable force in the evolving blockchain landscape.

Investor Profile

Polychain has backed more than 256 startups, with 30 new investments in the last 12 months alone. The firm has led 144 rounds, about 56% of its total and boasts 7 exits across its portfolio.

Investment Focus Highlights

  • Concentrates on Seed, Series A, Series Unknown rounds (top funding stages).
  • Majority of deals are located in United States, Singapore, Canada.
  • Strong thematic focus on Blockchain, Cryptocurrency, FinTech.
  • Led 17 rounds in the past year.
  • Typical check size: $2M – $25M.

Stage Focus

  • Seed (43%)
  • Series A (25%)
  • Series Unknown (14%)
  • Initial Coin Offering (6%)
  • Series B (5%)
  • Pre Seed (3%)
  • Series C (2%)
  • Series E (1%)

Country Focus

  • United States (58%)
  • Singapore (8%)
  • Canada (5%)
  • Switzerland (4%)
  • Seychelles (2%)
  • Japan (2%)
  • Australia (2%)
  • Cayman Islands (2%)
  • India (2%)
  • Israel (1%)

Industry Focus

  • Blockchain
  • Cryptocurrency
  • Fintech
  • Financial Services
  • Software
  • Information Technology
  • Web3
  • Decentralized Finance (Defi)
  • Internet
  • Finance
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FAQ

Frequently Asked Questions

Learn who this investor regularly partners with—both firms and angels—and explore their latest activity.

Who does Polychain frequently co-invest with?

Pantera Capital
North America, California, United States, Menlo Park
Co-Investments: 19
IOSG Ventures
Asia, Hong Kong Island, Hong Kong, Hong Kong
Co-Investments: 16
dao5
North America, Utah, United States, Virgin
Co-Investments: 18
Blockchain Capital
North America, California, United States, San Francisco
Co-Investments: 15
Coinbase Ventures
North America, California, United States, Oakland
Co-Investments: 37
Robot Ventures
North America, New York, United States, New York
Co-Investments: 18
Binance Labs
Europe, NA - Malta, Malta, Birkirkara
Co-Investments: 15
Hack VC
North America, California, United States, San Francisco
Co-Investments: 17
Dragonfly
North America, California, United States, San Francisco
Co-Investments: 18
Andreessen Horowitz
North America, California, United States, Menlo Park
Co-Investments: 25

Which angels does Polychain often collaborate with?

Balaji Srinivasan
Asia, Central Region, Singapore, Singapore
Shared Deals: 15
Bryan Pellegrino
North America, British Columbia, Canada, Vancouver
Shared Deals: 4
Sandeep Nailwal
Asia, Indonesia
Shared Deals: 9
Kain Warwick
Oceania, New South Wales, Australia, Sydney
Shared Deals: 4
GL
North America, NA - Puerto Rico, Puerto Rico, San Juan
Shared Deals: 5
MD
North America, New York, United States, New York
Shared Deals: 4
SR
Europe, Monaco
Shared Deals: 4
NR
North America, California, United States, San Francisco
Shared Deals: 13
FE
North America, California, United States, San Francisco
Shared Deals: 5
EG
North America, California, United States, San Francisco
Shared Deals: 6

What are some of recent deals done by Polychain?

180 Life Sciences

Menlo Park, California, United States

180 Life Sciences developing novel drugs for treating distinct inflammatory diseases.

BiopharmaBiotechnologyHealth CareLife Science
Post Ipo EquityJul 29, 2025
Amount Raised: $425,000,000
Digital Asset

New York, New York, United States

Digital Asset develops distributed ledger and smart contract infrastructure aimed at enabling synchronized finance across institutions.

BlockchainCryptocurrencyDeveloper PlatformDeveloper ToolsFinTech
Series EJun 24, 2025
Amount Raised: $135,000,000

Blueprint Finance develops protocols and infrastructure to advance on-chain finance.

FinanceFinancial ServicesInfrastructure
Series UnknownJun 23, 2025
Amount Raised: $9,500,000

DogeOS is a free program that helps people create apps and use cloud services for Dogecoin.

BlockchainCryptocurrencyWeb3
Series UnknownMay 6, 2025
Amount Raised: $6,900,000
Warlock Labs

Amsterdam, Noord-Holland, The Netherlands

Warlock Labs is a provider of an omni-chain liquidation engine that improves the safety and profitability of decentralized protocols.

FinanceFinancial Services
SeedMar 27, 2025
Amount Raised: $8,000,000
Level

New York, New York, United States

Level is a fintech company that develops stakblecoin backed by restaked dollar tokens.

BlockchainNon-Fungible Token (NFT)Web3
SeedMar 18, 2025
Amount Raised: $2,600,000

Biton is a full-chain ecology trading platform that offers services to simplify the trading process and mitigate cross-chain risks.

BlockchainCryptocurrencyTrading Platform
Series UnknownMar 10, 2025
Amount Raised: $20,000,000
Seismic

New York, New York, United States

Seismicy enables developers to establish innovative financial partnerships and investment instruments.

BlockchainDeveloper ToolsWeb3
SeedMar 6, 2025
Amount Raised: $7,000,000
Fluent Labs

California City, California, United States

Fluent Labs is a blockchain development company.

BlockchainCryptocurrencyWeb3
SeedFeb 19, 2025
Amount Raised: $8,000,000
Ethena

Lisbon, Lisboa, Portugal

Ethena is a decentralized finance protocol built on the Ethereum, offering a crypto-native synthetic dollar solution known as USDe.

BlockchainCryptocurrencyDecentralized Finance (DeFi)EthereumFinanceFinTech
UndisclosedFeb 2, 2025
Amount Raised: $100,000,000