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Sixty Degree Capital

North America, Ontario, Canada, Toronto

Description

Sixty Degree Capital is a Toronto-based venture capital firm dedicated to fostering innovation within the technology and healthcare sectors. Founded with a focus on early-stage companies, the firm aims to partner with visionary entrepreneurs who are developing disruptive solutions to complex challenges. Their investment philosophy emphasizes long-term partnerships, providing not just capital but also strategic guidance and access to a robust network to help portfolio companies scale effectively.

The firm primarily targets Seed and Series A funding rounds, seeking out companies that demonstrate strong potential for growth and significant market impact. Within healthcare, Sixty Degree Capital shows a particular interest in digital health, health tech, and solutions that improve patient outcomes or healthcare efficiency. In technology, their scope is broad, encompassing various software and platform innovations that can drive digital transformation. Notable companies in their portfolio include SeamlessMD, a digital health platform for surgical care, and MedStack, which provides a secure and compliant cloud platform for healthcare applications.

As of early 2024, Sixty Degree Capital has made approximately 10 investments, demonstrating a focused approach to its portfolio construction. The firm has also taken on the role of lead investor in at least 1 of these funding rounds, indicating a willingness to take a significant position in promising ventures. While specific typical check sizes are not publicly disclosed, their participation in early-stage rounds suggests investments aligned with the capital needs of Seed and Series A companies in the Canadian market. Sixty Degree Capital remains an active participant in the Canadian innovation ecosystem, committed to supporting the next generation of tech and health leaders.

Investor Profile

Sixty Degree Capital has backed more than 31 startups, with 3 new investments in the last 12 months alone. The firm has led 0 rounds, about 0% of its total and boasts 7 exits across its portfolio.

Investment Focus Highlights

  • Concentrates on Series B, Series C, Series E rounds (top funding stages).
  • Majority of deals are located in United States, Switzerland, Israel.
  • Strong thematic focus on Biotechnology, Health Care, Therapeutics.

Stage Focus

  • Series B (35%)
  • Series C (16%)
  • Series E (13%)
  • Series D (13%)
  • Series Unknown (10%)
  • Series A (6%)
  • Convertible Note (3%)
  • Seed (3%)

Country Focus

  • United States (81%)
  • Switzerland (10%)
  • Israel (3%)
  • Germany (3%)
  • Canada (3%)

Industry Focus

  • Biotechnology
  • Health Care
  • Therapeutics
  • Biopharma
  • Pharmaceutical
  • Medical
  • Software
  • Life Science
  • Precision Medicine
  • Artificial Intelligence (Ai)
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FAQ

Frequently Asked Questions

Learn who this investor regularly partners with—both firms and angels—and explore their latest activity.

Who does Sixty Degree Capital frequently co-invest with?

CA
North America, Massachusetts, United States, Boston
Co-Investments: 4
Catalio Capital Management
North America, New York, United States, New York
Co-Investments: 5
Google Ventures
North America, California, United States, Mountain View
Co-Investments: 4
Adage Capital Management
North America, Massachusetts, United States, Boston
Co-Investments: 4
RA Capital Management
North America, Massachusetts, United States, Boston
Co-Investments: 4
Amzak Health Investors
North America, New York, United States, New York
Co-Investments: 4
CAM Capital
North America, New York, United States, New York
Co-Investments: 4
Aisling Capital
North America, New York, United States, New York
Co-Investments: 4
Invus
North America, New York, United States, New York
Co-Investments: 5
Fidelity
North America, Massachusetts, United States, Boston
Co-Investments: 5

Which angels does Sixty Degree Capital often collaborate with?

AP
North America, California, United States, Palo Alto
Shared Deals: 1
GF
North America, California, United States
Shared Deals: 2
AG
North America, New Jersey, United States, New Brunswick
Shared Deals: 1
CE
Europe, Berlin, Germany, Berlin
Shared Deals: 1
TG
North America, California, United States
Shared Deals: 1
MA
North America, California, United States
Shared Deals: 1
BC
North America, California, United States, San Francisco
Shared Deals: 1
LT
North America, California, United States, San Jose
Shared Deals: 1

What are some of recent deals done by Sixty Degree Capital?

Droidrun

Osnabrück, Niedersachsen, Germany

Droidrun develops software that allows AI agents to access smartphones and control apps.

AnalyticsArtificial Intelligence (AI)Infrastructure
Pre SeedJul 24, 2025
Amount Raised: $2,472,523
Empirical Security

Chicago, Illinois, United States

Empirical builds mathematical models for security data.

Artificial Intelligence (AI)Cyber SecurityNetwork Security
SeedJul 17, 2025
Amount Raised: $11,935,326
Pokee AI

Bellevue, Washington, United States

Pokee AI is an AI company that offers an interactive, personalized, and efficient AI agent that helps in planning, reasoning and tool usage.

Artificial Intelligence (AI)SaaSSoftware
SeedJun 10, 2025
Amount Raised: $11,929,999
GlycoEra

Schlieren, Zurich, Switzerland

GlycoEra is a biotechnology research company that produces extracellular protein degraders for the treatment of autoimmune diseases.

BiotechnologyHealth CareMedical
Series BMay 27, 2025
Amount Raised: $130,000,000
Eclypsium

Portland, Oregon, United States

Eclypsium offers a platform for supply chain security for IT infrastructure.

Cyber SecurityEnterpriseInformation Technology
Series CJan 28, 2025
Amount Raised: $45,000,000
FogPharma

Cambridge, Massachusetts, United States

FogPharma is a biopharmaceutical firm that develops precision medicines for the vast majority of therapeutic targets.

BiopharmaBiotechnologyHealth CareLife SciencePharmaceuticalPrecision Medicine
Series EMar 1, 2024
Amount Raised: $145,000,000
NextPoint Therapeutics

Cambridge, Massachusetts, United States

NextPoint Therapeutics is a clinical-stage biotechnology company that develops therapeutics to treat cancer patients.

BiotechnologyHealth CareLife ScienceTherapeutics
Series BFeb 14, 2024
Amount Raised: $42,500,000
Cato Networks

Tel Aviv, Tel Aviv, Israel

Cato Networks is a provider of a SASE platform that offers a secure enterprise network connection to locations, people, and data.

Cloud ComputingInformation TechnologyNetwork SecuritySoftware
Series UnknownSep 19, 2023
Amount Raised: $238,000,000
NextPoint Therapeutics

Cambridge, Massachusetts, United States

NextPoint Therapeutics is a clinical-stage biotechnology company that develops therapeutics to treat cancer patients.

BiotechnologyHealth CareLife ScienceTherapeutics
Series BJan 10, 2023
Amount Raised: $80,000,000
Bionaut Labs

Los Angeles, California, United States

Bionaut Labs revolutionizes the treatment of central nervous system disorders with its precision medicine treatment modality.

BiopharmaBiotechnologyHealth CarePrecision MedicineTherapeutics
Series BNov 28, 2022
Amount Raised: $43,200,000