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Soleus Capital

North America, Connecticut, United States, Greenwich

Description

Soleus Capital Management, L.P. is a distinguished private investment firm headquartered in Greenwich, Connecticut, established in 2009. The firm has carved out a specialized niche within the healthcare sector, demonstrating a keen focus on biotechnology, pharmaceuticals, medical devices, and diagnostics. Operating as a "crossover fund," Soleus Capital strategically deploys capital into both public and private companies, leveraging a deep, fundamental, and research-driven approach to identify and support promising innovators within the life sciences ecosystem. Their investment philosophy emphasizes long-term value creation through rigorous due diligence and a comprehensive understanding of market dynamics and scientific advancements.

A testament to their robust investment strategy and market confidence, Soleus Capital successfully closed its second fund, Soleus Capital Fund II, L.P., at an impressive $1.1 billion in 2018. This significant capital base underscores their capacity for substantial investments. The firm's Assets Under Management (AUM) have consistently remained around the $1.1 billion mark in recent years, reflecting their stable and impactful presence in the healthcare investment landscape. This substantial pool of capital enables them to engage in meaningful partnerships and provide significant financial backing to their portfolio companies.

Soleus Capital typically targets growth-stage private companies and pre-IPO opportunities, often participating in large, syndicated funding rounds. Their investment activity frequently involves contributing to rounds that exceed $100 million, such as their participation in the $100 million Series B for ReCode Therapeutics in 2021, or the $150 million Series B for Third Harmonic Bio in the same year. While specific individual check sizes can vary based on the round structure and the firm's stake, their involvement in such substantial financings indicates a typical first cheque size ranging from tens of millions of dollars, reflecting their commitment to providing significant growth capital.

The firm's expertise in healthcare, combined with its flexible investment mandate across public and private markets, positions Soleus Capital as a key financial partner for companies navigating complex development and commercialization pathways. Their strategic investments aim to accelerate the growth and market penetration of innovative healthcare solutions, contributing to advancements across the sector.

Investor Profile

Soleus Capital has backed more than 68 startups, with 11 new investments in the last 12 months alone. The firm has led 10 rounds, about 15% of its total and boasts 31 exits across its portfolio.

Investment Focus Highlights

  • Concentrates on Post Ipo Equity, Series B, Series C rounds (top funding stages).
  • Majority of deals are located in United States, United Kingdom, Canada.
  • Strong thematic focus on Biotechnology, Health Care, Therapeutics.
  • Led 2 rounds in the past year.
  • Typical check size: $10M – $75M.

Stage Focus

  • Post Ipo Equity (32%)
  • Series B (22%)
  • Series C (19%)
  • Series D (12%)
  • Series A (4%)
  • Series Unknown (4%)
  • Post Ipo Debt (1%)
  • Undisclosed (1%)
  • Series E (1%)
  • Series F (1%)

Country Focus

  • United States (79%)
  • United Kingdom (9%)
  • Canada (4%)
  • Denmark (3%)
  • Israel (1%)
  • France (1%)

Industry Focus

  • Biotechnology
  • Health Care
  • Therapeutics
  • Medical Device
  • Medical
  • Pharmaceutical
  • Health Diagnostics
  • Life Science
  • Genetics
  • Biopharma
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FAQ

Frequently Asked Questions

Learn who this investor regularly partners with—both firms and angels—and explore their latest activity.

Who does Soleus Capital frequently co-invest with?

Farallon Capital Management
North America, California, United States, San Francisco
Co-Investments: 12
CA
North America, Massachusetts, United States, Boston
Co-Investments: 11
Samsara BioCapital
North America, California, United States, Palo Alto
Co-Investments: 9
DC
North America, Illinois, United States, Chicago
Co-Investments: 9
RTW Investments
North America, New York, United States, New York
Co-Investments: 11
RA Capital Management
North America, Massachusetts, United States, Boston
Co-Investments: 23
Deep Track Capital
North America, Connecticut, United States, Greenwich
Co-Investments: 10
Perceptive Advisors
North America, New York, United States, New York
Co-Investments: 18
Sands Capital Ventures
North America, Virginia, United States, Arlington
Co-Investments: 10
Janus Henderson Investors
Europe, England, United Kingdom, London
Co-Investments: 14

Which angels does Soleus Capital often collaborate with?

ME
Europe, England, United Kingdom
Shared Deals: 1
JM
North America, United States
Shared Deals: 1
BS
North America, Minnesota, United States, Minneapolis
Shared Deals: 1
AU
Europe, Hallands Lan, Sweden, Kungsbacka
Shared Deals: 1
Mark W. Hahn
North America, North Carolina, United States, Chapel Hill
Shared Deals: 1
VS
North America, Massachusetts, United States, Boston
Shared Deals: 1
David Zaccardelli
North America, United States
Shared Deals: 1
DE
Europe, Zurich, Switzerland, Zürich
Shared Deals: 1

What are some of recent deals done by Soleus Capital?

Crescent Biopharma

Rockville, Maryland, United States

Crescent Biopharma is a biotechnology firm focused on developing novel precision-engineered medicines.

BiotechnologyHealth CareMedical Device
Post Ipo EquityJun 16, 2025
Amount Raised: $200,000,000
Pillar Biosciences

Natick, Massachusetts, United States

Pillar Biosciences specializes in sequencing technology platform and proprietary data analysis toolkit.

BiotechnologyHealth CareHealth Diagnostics
Series UnknownMay 27, 2025
Amount Raised: $34,500,000
Jade Biosciences

Waltham, Massachusetts, United States

Jade Biosciences is developing transformative therapies to redefine the standard of care for inflammation and immunology indications.

Health CareTherapeutics
Post Ipo EquityApr 29, 2025
Amount Raised: $300,000,000
Neurona Therapeutics

San Francisco, California, United States

Neurona Therapeutics develops cell therapies for neurological disorders, focusing on treatments like NRTX-1001 for epilepsy.

BiotechnologyHealth CareTherapeutics
Series FApr 3, 2025
Amount Raised: $102,000,000
OrganOx

Oxford, Oxfordshire, United Kingdom

OrganOx is a medical technology company.

Health CareMedicalMedical Device
Series UnknownFeb 24, 2025
Amount Raised: $142,000,000
Tectonic Therapeutic

Allston, Massachusetts, United States

Tectonic Therapeutic is a biotechnology company which focuses on scientific research in biochemistry and molecular pharmacology.

Biotechnology
Post Ipo EquityFeb 3, 2025
Amount Raised: $185,000,000
Beta Bionics

Irvine, California, United States

Beta Bionics is a biotechnology company that provides software to reduce the burden of diabetes care.

BiotechnologyDiabetesMedical Device
Series ENov 13, 2024
Amount Raised: $60,000,000
Blue Earth Therapeutics

Oxford, Oxfordshire, United Kingdom

Blue Earth Therapeutics is a radiopharmaceutical company that specializes in the advancement of radiotherapeutics to treat cancer patients.

Health CareMedicalPharmaceuticalTherapeutics
Series AOct 30, 2024
Amount Raised: $76,500,000

Crescent Biopharma is a biotechnology firm focused on developing novel precision-engineered medicines.

BiotechnologyHealth CareMedical Device
UndisclosedOct 29, 2024
Amount Raised: $200,000,000
Inhibikase Therapeutics

Atlanta, Georgia, United States

Inhibikase Therapeutics is a developer of cellular Abelson tyrosine kinase inhibitors to treat infections and other diseases.

Health CareHealth DiagnosticsTherapeutics
Post Ipo EquityOct 9, 2024
Amount Raised: $110,000,000