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RTW Investments

North America, New York, United States, New York

Description

RTW Investments is a prominent New York-based investment firm specializing in the global healthcare sector, with a particular emphasis on life sciences. Founded with a mission to identify and support companies developing transformative medical innovations, RTW employs a unique dual strategy, investing across both private and public markets. This integrated approach allows them to support companies from their early-to-mid private stages, through to their public market debut and beyond, providing long-term capital and strategic guidance. Their investment philosophy is deeply rooted in scientific and medical expertise, enabling them to conduct rigorous due diligence on complex biotechnological and pharmaceutical advancements.

The firm is known for its high-convection investments in companies that are pioneering novel therapies, diagnostics, and medical technologies. RTW typically engages with private companies from Series A rounds onwards, often taking a lead or co-lead position in significant financing rounds. Their portfolio reflects a strong focus on areas such as oncology, rare diseases, neuroscience, and genetic medicines, where substantial capital is often required for research, development, and clinical trials. They are not merely financial investors but aim to be active partners, leveraging their extensive network and industry insights to help accelerate the growth and success of their portfolio companies.

With approximately $5.4 billion in regulatory assets under management as of Q1 2024, RTW Investments has the capacity to deploy significant capital into promising healthcare ventures. For instance, they have notably led or participated in numerous large financing rounds, such as a $100 million Series B for ReNAgade Therapeutics in 2023, demonstrating their commitment to funding substantial scientific endeavors. While precise first check sizes can vary, their typical private equity investments reflect the capital-intensive nature of the biotech industry, often ranging from multi-million dollar commitments in Series A rounds to substantial nine-figure investments in later-stage or pre-IPO financings.

RTW Investments has established itself as a key financial partner in the healthcare ecosystem, recognized for its ability to identify and nurture companies with the potential to significantly impact patient care. Their blend of scientific acumen, flexible investment mandates, and substantial capital resources positions them as a critical enabler for the next generation of healthcare breakthroughs, from early-stage innovation to global market leadership.

Investor Profile

RTW Investments has backed more than 119 startups, with 21 new investments in the last 12 months alone. The firm has led 32 rounds, about 27% of its total and boasts 54 exits across its portfolio.

Investment Focus Highlights

  • Concentrates on Post Ipo Equity, Series B, Series C rounds (top funding stages).
  • Majority of deals are located in United States, United Kingdom, Switzerland.
  • Strong thematic focus on Biotechnology, Health Care, Therapeutics.
  • Led 5 rounds in the past year.
  • Typical check size: $25M – $150M.

Stage Focus

  • Post Ipo Equity (33%)
  • Series B (27%)
  • Series C (15%)
  • Series A (10%)
  • Series D (8%)
  • Private Equity (3%)
  • Series G (1%)
  • Post Ipo Debt (1%)
  • Series Unknown (1%)
  • Undisclosed (1%)

Country Focus

  • United States (79%)
  • United Kingdom (5%)
  • Switzerland (4%)
  • China (3%)
  • Canada (3%)
  • Ireland (2%)
  • Germany (2%)
  • The Netherlands (1%)

Industry Focus

  • Biotechnology
  • Health Care
  • Therapeutics
  • Medical
  • Pharmaceutical
  • Life Science
  • Biopharma
  • Medical Device
  • Genetics
  • Health Diagnostics
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FAQ

Frequently Asked Questions

Learn who this investor regularly partners with—both firms and angels—and explore their latest activity.

Who does RTW Investments frequently co-invest with?

OrbiMed
North America, New York, United States, New York
Co-Investments: 16
Surveyor Capital
North America, Illinois, United States, Chicago
Co-Investments: 15
CA
North America, Massachusetts, United States, Boston
Co-Investments: 21
Venrock Healthcare Capital Partners
North America, California, United States, Palo Alto
Co-Investments: 20
RA Capital Management
North America, Massachusetts, United States, Boston
Co-Investments: 25
Deep Track Capital
North America, Connecticut, United States, Greenwich
Co-Investments: 14
Perceptive Advisors
North America, New York, United States, New York
Co-Investments: 33
Logos Capital
North America, California, United States, San Francisco
Co-Investments: 17
Janus Henderson Investors
Europe, England, United Kingdom, London
Co-Investments: 21
Boxer Capital
North America, Florida, United States, Windermere
Co-Investments: 18

Which angels does RTW Investments often collaborate with?

SK
North America, California, United States, Los Angeles
Shared Deals: 1
RK
North America, California, United States, Los Angeles
Shared Deals: 1
CG
North America, Massachusetts, United States, Boston
Shared Deals: 1

What are some of recent deals done by RTW Investments?

CORXEL Pharmaceuticals

Shanghai, Shanghai, China

CORXEL Pharmaceuticals is a biotechnology company that develops science and medicines for underserved patients.

BiotechnologyHealth CareMedical
Series DJan 22, 2026
Amount Raised: $287,000,000
Ocugen

Malvern, Pennsylvania, United States

Ocugen is a biotechnology company that develops novel gene and cell therapies to improve health and patient outcomes.

BiopharmaBiotechnologyHealth Care
Post Ipo EquityJan 21, 2026
Amount Raised: $22,500,000
Century Therapeutics

Philadelphia, Pennsylvania, United States

Century Therapeutics is a biotechnology company that develops cell therapies for hematological and solid tumor malignancies.

BiotechnologyHealth CareHealth Diagnostics
Post Ipo EquityJan 8, 2026
Amount Raised: $135,000,000
Kalaris Therapeutics

Houston, Texas, United States

Kalaris Therapeutics is a biopharmaceutical company that provides development and commercialization of treatments for retinal diseases.

BiotechnologyClinical TrialsPharmaceutical
Post Ipo EquityDec 17, 2025
Amount Raised: $50,000,000
Yarrow

New York, New York, United States

Yarrow is developing a first-in-class antibody targeting TSHR for the treatment of Graves’ disease and thyroid eye disease.

Business IntelligenceHealth CareMedical
Series UnknownDec 17, 2025
Amount Raised: $200,000,000
Kailera Therapeutics

Waltham, Massachusetts, United States

Kailera Therapeutics develops next-generation injectable and oral therapies for chronic weight management.

BiotechnologyPharmaceuticalTherapeutics
Series BOct 14, 2025
Amount Raised: $600,000,000
Ensoma

Boston, Massachusetts, United States

Ensomaa is a genomic medicine company that develops on one-time in vivo treatments for immuno-oncology and other therapeutic applications.

BiotechnologyGeneticsLife ScienceMedicalOncologyTherapeutics
Series UnknownSep 22, 2025
Amount Raised: $53,000,000
Belite Bio

San Diego, California, United States

Belite Bio is a clinical stage biopharmaceutical drug development company.

BiotechnologyHealth CarePharmaceutical
Post Ipo EquitySep 8, 2025
Amount Raised: $125,000,000
Aquestive Therapeutics

Warren, New Jersey, United States

Aquestive is a specialty pharmaceutical company that advances and commercializes medicines to solve critical healthcare problems.

Pharmaceutical
Post Ipo EquityAug 14, 2025
Amount Raised: $85,000,000
Inmagene Biopharmaceuticals

San Diego, California, United States

Inmagene is a clinical-stage biotech company developing innovative and differentiated therapies for immunological and inflammatory diseases.

BiopharmaBiotechnologyHealth Care
Post Ipo EquityJul 28, 2025
Amount Raised: $75,000,000

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