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Octagon Capital Advisors

North America, New York, United States, New York

Description

Octagon Capital Advisors is a New York-based investment firm with a singular focus on the global healthcare sector. The firm distinguishes itself through a comprehensive investment strategy that spans both public and private companies, demonstrating flexibility across the capital structure, including equity, debt, and structured solutions. Octagon positions itself as a long-term partner, aiming to collaborate with management teams to foster the growth and sustainability of their portfolio companies. Their expertise covers the entire lifecycle of a company, from early-stage growth ventures to established, mature public entities.

The firm's investment philosophy is deeply rooted in a thorough understanding of the healthcare industry, leveraging its team's extensive experience in healthcare investing, mergers and acquisitions, and operational management. This deep sector knowledge allows Octagon to identify and support innovative companies poised for significant impact within the complex healthcare landscape. While they engage in private investments, a notable portion of their publicly disclosed portfolio comprises public companies, indicating a strong capability and inclination towards public market participation, including strategic investments in publicly traded healthcare firms.

For its private investments, Octagon Capital Advisors typically targets companies requiring substantial capital for growth and development. For instance, the firm participated in the Series A funding round for Aura Biosciences, which raised $30 million, and subsequently in its $40 million Series B round. These examples suggest that Octagon is comfortable deploying significant capital, often contributing multi-million dollar checks to support promising healthcare innovations. Based on their participation in such substantial funding rounds and their focus on later-stage private and public companies, Octagon Capital Advisors' initial investment checks likely range from approximately $5 million for significant minority stakes in growth-stage companies, extending up to $50 million or more for lead positions in larger private rounds or substantial public market investments. This broad range reflects their adaptable approach to capital deployment across the diverse healthcare ecosystem.

Investor Profile

Octagon Capital Advisors has backed more than 59 startups, with 2 new investments in the last 12 months alone. The firm has led 4 rounds, about 7% of its total and boasts 24 exits across its portfolio.

Investment Focus Highlights

  • Concentrates on Series C, Series B, Post Ipo Equity rounds (top funding stages).
  • Majority of deals are located in United States, China, Switzerland.
  • Strong thematic focus on Biotechnology, Health Care, Therapeutics.
  • Typical check size: $5M – $50M.

Stage Focus

  • Series C (31%)
  • Series B (25%)
  • Post Ipo Equity (17%)
  • Series A (12%)
  • Series E (5%)
  • Series Unknown (5%)
  • Series D (3%)
  • Private Equity (2%)

Country Focus

  • United States (56%)
  • China (37%)
  • Switzerland (3%)
  • United Kingdom (2%)
  • Singapore (2%)

Industry Focus

  • Biotechnology
  • Health Care
  • Therapeutics
  • Life Science
  • Pharmaceutical
  • Medical
  • Biopharma
  • Oncology
  • Medical Device
  • Health Diagnostics
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FAQ

Frequently Asked Questions

Learn who this investor regularly partners with—both firms and angels—and explore their latest activity.

Who does Octagon Capital Advisors frequently co-invest with?

OrbiMed
North America, New York, United States, New York
Co-Investments: 13
Casdin Capital
North America, New York, United States, New York
Co-Investments: 8
RTW Investments
North America, New York, United States, New York
Co-Investments: 6
RA Capital Management
North America, Massachusetts, United States, Boston
Co-Investments: 12
Ally Bridge Group
Asia, Hong Kong Island, Hong Kong, Hong Kong
Co-Investments: 6
Perceptive Advisors
North America, New York, United States, New York
Co-Investments: 6
Logos Capital
North America, California, United States, San Francisco
Co-Investments: 6
Lilly Asia Ventures
Asia, Shanghai, China, Shanghai
Co-Investments: 13
Janus Henderson Investors
Europe, England, United Kingdom, London
Co-Investments: 7
Invus
North America, New York, United States, New York
Co-Investments: 6

Which angels does Octagon Capital Advisors often collaborate with?

MC
North America, California, United States, San Francisco
Shared Deals: 1
Adrian Cheng
Asia, Hong Kong
Shared Deals: 2

What are some of recent deals done by Octagon Capital Advisors?

Verastem Oncology

Needham, Massachusetts, United States

Verastem is a biopharmaceutical company developing new medicines to improve the lives of patients with RAS/MAPK pathway-driven cancers.

BiopharmaBiotechnologyPharmaceutical
Post Ipo EquityApr 25, 2025
Amount Raised: $75,000,000
Numab

Wadenswil, Zurich, Switzerland

Numab is a biotechnology company that offers antibody-based therapeutics for the treatment of severe diseases.

BiopharmaBiotechnologyHealth CareHealth DiagnosticsLife ScienceMedicalTherapeutics
Series CJan 9, 2025
Amount Raised: $54,939,501
Bluejay Therapeutics

San Mateo, California, United States

Bluejay Therapeutics is a private biopharmaceutical company focused on the development of cures for infectious diseases.

BiotechnologyHealth CarePharmaceutical
Series CMay 9, 2024
Amount Raised: $182,000,000
Century Therapeutics

Philadelphia, Pennsylvania, United States

Century Therapeutics is a biotechnology company that develops cell therapies for hematological and solid tumor malignancies.

BiotechnologyHealth CareHealth Diagnostics
Post Ipo EquityApr 11, 2024
Amount Raised: $60,000,000
Unicycive Therapeutics

Los Altos, California, United States

Unicycive Therapeutics provides development programs that focus on treating kidney diseases with unmet medical needs.

BiotechnologyHealth CareHealth DiagnosticsMedical
Post Ipo EquityMar 14, 2024
Amount Raised: $50,000,000
Regulus Therapeutics

San Diego, California, United States

Regulus Therapeutics is a clinical stage biopharmaceutical company focused on the development and discovery of microRNA therapeutics.

BiotechnologyGeneticsHealth CareTherapeutics
Post Ipo EquityMar 12, 2024
Amount Raised: $100,000,000
MindMed

New York, New York, United States

MindMed provides psychedelic-inspired medicines and therapies for substance abuse disorders and other mental illnesses.

BiotechnologyHealth CarePharmaceutical
Post Ipo EquityMar 7, 2024
Amount Raised: $175,000,000
ProfoundBio

Seattle, Washington, United States

ProfoundBio is a developer of targeted therapeutics intended for patients with cancer.

BiotechnologyOncologyTherapeutics
Series BFeb 13, 2024
Amount Raised: $112,000,000
Tenaya Therapeutics

San Francisco, California, United States

Tenaya Therapeutics is a developer of novel therapies designed to offer treatment for heart disease.

BiopharmaBiotechnologyHealth CareTherapeutics
Post Ipo EquityFeb 8, 2024
Amount Raised: $50,000,000
Pepgen

Oxford, Oxfordshire, United Kingdom

PepGen is empowering nucleic acid therapeutics to go the distance.

BiotechnologyClinical TrialsMedical
Post Ipo EquityFeb 7, 2024
Amount Raised: $80,100,000