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Pivotal bioVenture Partners

North America, California, United States, San Francisco

Description

Pivotal bioVenture Partners is a prominent San Francisco-based venture capital firm dedicated to investing in early-stage biotechnology companies. Established in 2017, the firm focuses on identifying and supporting innovative ventures developing therapeutics, diagnostics, and medical devices that address areas of high unmet medical need. Their investment philosophy centers on partnering with visionary entrepreneurs and scientific founders to translate groundbreaking research into impactful healthcare solutions.

The firm primarily targets companies in their Seed, Series A, and early Series B funding rounds, often taking a lead or co-lead investor role. Pivotal bioVenture Partners is known for its hands-on approach, leveraging its deep industry expertise and extensive network to provide strategic guidance and operational support to its portfolio companies. They seek opportunities where their capital and insights can significantly accelerate the development and commercialization of novel biotechnologies, aiming to build category-defining companies.

Pivotal bioVenture Partners manages substantial capital, with its total assets under management (AUM) across multiple funds reaching approximately $1.2 billion. This includes the successful close of Pivotal bioVenture Partners Fund II and Fund III, each securing $400 million in commitments. The firm has built a diverse portfolio of over 50 investments, spanning various therapeutic areas and technological platforms. While headquartered in San Francisco, their investment scope extends globally, notably through their dedicated China fund, which underscores their commitment to fostering innovation in key biotech hubs worldwide.

Through their strategic investments and active portfolio management, Pivotal bioVenture Partners continues to play a significant role in advancing the biotechnology landscape. Their commitment to early-stage innovation, coupled with substantial financial backing, positions them as a key partner for emerging biotech companies seeking to make a transformative impact on global health.

Investor Profile

Pivotal bioVenture Partners has backed more than 37 startups, with 3 new investments in the last 12 months alone. The firm has led 14 rounds, about 38% of its total and boasts 16 exits across its portfolio.

Investment Focus Highlights

  • Concentrates on Series B, Series C, Series A rounds (top funding stages).
  • Majority of deals are located in United States, Iceland, China.
  • Strong thematic focus on Biotechnology, Health Care, Pharmaceutical.
  • Led 1 rounds in the past year.
  • Typical check size: $5M – $25M.

Stage Focus

  • Series B (46%)
  • Series C (19%)
  • Series A (14%)
  • Series D (8%)
  • Seed (5%)
  • Undisclosed (3%)
  • Convertible Note (3%)
  • Post Ipo Equity (3%)

Country Focus

  • United States (76%)
  • Iceland (8%)
  • China (5%)
  • Canada (3%)
  • United Kingdom (3%)
  • Ireland (3%)
  • Switzerland (3%)

Industry Focus

  • Biotechnology
  • Health Care
  • Pharmaceutical
  • Biopharma
  • Therapeutics
  • Medical
  • Life Science
  • Health Diagnostics
  • Oncology
  • Artificial Intelligence (Ai)
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FAQ

Frequently Asked Questions

Learn who this investor regularly partners with—both firms and angels—and explore their latest activity.

Who does Pivotal bioVenture Partners frequently co-invest with?

OrbiMed
North America, New York, United States, New York
Co-Investments: 5
Sofinnova Investments
North America, California, United States, Menlo Park
Co-Investments: 7
Surveyor Capital
North America, Illinois, United States, Chicago
Co-Investments: 7
CA
North America, Massachusetts, United States, Boston
Co-Investments: 5
RA Capital Management
North America, Massachusetts, United States, Boston
Co-Investments: 9
Frazier Healthcare Partners
North America, Washington, United States, Seattle
Co-Investments: 5
Novo Holdings
Europe, Hovedstaden, Denmark, Hellerup
Co-Investments: 8
Longitude Capital
North America, California, United States, Menlo Park
Co-Investments: 6
Rock Springs Capital
North America, Maryland, United States, Baltimore
Co-Investments: 7
Vivo Capital
North America, California, United States, Palo Alto
Co-Investments: 6

What are some of recent deals done by Pivotal bioVenture Partners?

Avalyn Pharma

Seattle, Washington, United States

Avalyn Pharma is a biopharma company developing therapies for the treatment of idiopathic pulmonary fibrosis and other respiratory diseases.

BiopharmaBiotechnologyMedicalPharmaceutical
Series DJul 22, 2025
Amount Raised: $100,000,000
Mosanna Therapeutics

Redwood City, California, United States

Mosanna Therapeutics develops a nasal spray for treating obstructive sleep apnea.

BiotechnologyPharmaceuticalTherapeutics
Series AJun 9, 2025
Amount Raised: $80,000,000
Windward Bio

Basel, Basel-Stadt, Switzerland

Windward Bio develops monoclonal antibodies for advanced immunological diseases.

BiotechnologyLife ScienceMedical
Series AJan 10, 2025
Amount Raised: $200,000,000
Evommune

Palo Alto, California, United States

Evommune is a biotechnology company that develops therapeutics that halt progressive disease and address their symptoms.

BiotechnologyHealth CareLife Science
Series COct 31, 2024
Amount Raised: $115,000,000
Zenas BioPharma

Waltham, Massachusetts, United States

Zenas BioPharma is a biopharmaceutical company that focuses on developing immune-based therapies for patients.

BiopharmaHealth CarePharmaceutical
Series CMay 7, 2024
Amount Raised: $200,000,000
BioAge Labs

Richmond, California, United States

BioAge Labs is a clinical-stage biotechnology company that develops therapeutics to treat obesity and metabolic diseases.

BiopharmaBiotechnologyLife ScienceTherapeutics
Series DFeb 13, 2024
Amount Raised: $170,000,000
Avalyn Pharma

Seattle, Washington, United States

Avalyn Pharma is a biopharma company developing therapies for the treatment of idiopathic pulmonary fibrosis and other respiratory diseases.

BiopharmaBiotechnologyMedicalPharmaceutical
Series CSep 27, 2023
Amount Raised: $175,000,000
Evommune

Palo Alto, California, United States

Evommune is a biotechnology company that develops therapeutics that halt progressive disease and address their symptoms.

BiotechnologyHealth CareLife Science
Series BApr 26, 2023
Amount Raised: $50,000,000
Heranova Lifesciences

Huangpu, Shanghai, China

Hekaiwei is a provider of innovative solutions for women's health.

Health CareMedical
SeedMar 8, 2023
Amount Raised: $10,000,000
Oculis

Reykjavík, Gullbringusysla, Iceland

Oculis is a clinical-stage biopharmaceutical development company focusing on ophthalmic drugs and novel drug delivery.

BiotechnologyHealth CarePharmaceutical
Post Ipo EquityMar 3, 2023
Amount Raised: $91,000,000