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F-Prime Capital

North America, Massachusetts, United States, Cambridge

Description

F-Prime Capital is a prominent global venture capital firm with a distinctive dual focus on healthcare and technology sectors. As an affiliate of Fidelity Investments, the firm benefits from deep financial roots and a long-term investment horizon, allowing it to provide patient capital and strategic support to its portfolio companies. Headquartered in Cambridge, Massachusetts, F-Prime has established itself as a significant player in the venture ecosystem, known for its rigorous due diligence and hands-on approach.

The firm's investment strategy spans various stages, from seed to growth, with a particular emphasis on leading or co-leading early-stage rounds, including Seed, Series A, and Series B financings. Within healthcare, F-Prime targets innovative companies in biotech, medtech, and digital health, seeking to back breakthroughs that can transform patient care. In the technology realm, their interests lie in fintech, enterprise technology, and cybersecurity, identifying disruptive solutions that address critical business needs. Their global footprint allows them to source opportunities and support companies across different geographies.

F-Prime Capital is well-capitalized, having recently closed substantial funds to fuel its investment activities. In 2021, the firm announced the closing of a $500 million healthcare fund, followed by a $500 million technology fund in 2022, demonstrating significant capital deployment capacity. For typical first checks, F-Prime's initial investments generally range from approximately $2 million for seed-stage companies to $25 million or more for leading Series A or B rounds, reflecting their commitment to providing meaningful capital to accelerate growth. The firm boasts a strong track record, having invested in over 200 companies, leading to more than 50 IPOs and M&A events, underscoring their success in identifying and nurturing high-potential ventures. This strategic approach, combined with their extensive network and operational expertise, positions F-Prime Capital as a valuable partner for entrepreneurs aiming to build category-defining companies in their specialized domains.

Investor Profile

F-Prime Capital has backed more than 438 startups, with 33 new investments in the last 12 months alone. The firm has led 102 rounds, about 23% of its total and boasts 94 exits across its portfolio.

Investment Focus Highlights

  • Concentrates on Series A, Series B, Series C rounds (top funding stages).
  • Majority of deals are located in United States, United Kingdom, China.
  • Strong thematic focus on Health Care, Biotechnology, Medical.
  • Led 6 rounds in the past year.
  • Typical check size: $2M – $25M.

Stage Focus

  • Series A (33%)
  • Series B (28%)
  • Series C (13%)
  • Seed (9%)
  • Series Unknown (8%)
  • Series D (5%)
  • Series E (1%)

Country Focus

  • United States (79%)
  • United Kingdom (6%)
  • China (5%)
  • India (3%)
  • Japan (2%)
  • Switzerland (1%)
  • Chile (1%)

Industry Focus

  • Health Care
  • Biotechnology
  • Medical
  • Therapeutics
  • Software
  • Pharmaceutical
  • Medical Device
  • Fintech
  • Financial Services
  • Information Technology
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FAQ

Frequently Asked Questions

Learn who this investor regularly partners with—both firms and angels—and explore their latest activity.

Who does F-Prime Capital frequently co-invest with?

OrbiMed
North America, New York, United States, New York
Co-Investments: 21
Google Ventures
North America, California, United States, Mountain View
Co-Investments: 26
New Enterprise Associates
North America, California, United States, Menlo Park
Co-Investments: 18
Y Combinator
North America, California, United States, Mountain View
Co-Investments: 20
.406 Ventures
North America, Massachusetts, United States, Boston
Co-Investments: 16
Polaris Partners
North America, Massachusetts, United States, Boston
Co-Investments: 20
Maverick Ventures
North America, California, United States, San Francisco
Co-Investments: 17
Eight Roads Ventures
Europe, England, United Kingdom, London
Co-Investments: 129
Venrock
North America, California, United States, Palo Alto
Co-Investments: 16
ARCH Venture Partners
North America, Illinois, United States, Chicago
Co-Investments: 33

Which angels does F-Prime Capital often collaborate with?

LW
North America, Washington, United States, Seattle
Shared Deals: 2
PS
North America, Massachusetts, United States, Boston
Shared Deals: 2
RK
North America, New York, United States, New York
Shared Deals: 3
JR
North America, California, United States, San Francisco
Shared Deals: 2
JB
North America, Massachusetts, United States, Boston
Shared Deals: 3
LG
North America, California, United States, San Francisco
Shared Deals: 5
CB
North America, Massachusetts, United States, Boston
Shared Deals: 4
ES
North America, New Jersey, United States, Princeton
Shared Deals: 2
EG
North America, California, United States, San Francisco
Shared Deals: 3
RS
North America, Washington, United States, Seattle
Shared Deals: 2

What are some of recent deals done by F-Prime Capital?

Tenpoint Therapeutics

Camborne, Cornwall, United Kingdom

Tenpoint Therapeutics is a biotechnology company pursuing vision-restoring engineered cell-based therapeutics.

BiotechnologyProduct Research
Series BJan 28, 2026
Amount Raised: $85,000,000
Alfred

Miami, Florida, United States

Alfred Pay enables real-time payments across Latin America with a single API, focusing on financial inclusion.

Financial ServicesPaymentsTransaction Processing
Series AJan 26, 2026
Amount Raised: $15,000,000
Unbox Robotics

Bangalore, Karnataka, India

Unbox Robotics builds on-demand AI-driven warehouse robotics solutions to automate and improve logistics operations.

Artificial Intelligence (AI)Industrial AutomationIntelligent SystemsLogisticsMachine LearningRoboticsSupply Chain ManagementWarehouse Automation
Series BJan 20, 2026
Amount Raised: $28,000,000
Unbox Robotics

Bangalore, Karnataka, India

Unbox Robotics builds on-demand AI-driven warehouse robotics solutions to automate and improve logistics operations.

Artificial Intelligence (AI)Industrial AutomationIntelligent SystemsLogisticsMachine LearningRoboticsSupply Chain ManagementWarehouse Automation
Secondary MarketJan 20, 2026
Meld

Los Altos, California, United States

Meld is a "Fintech as a Service" platform that enables developers to embed any financial experience into their product.

CryptocurrencyE-Commerce PlatformsFinancial ServicesFinTechMobile PaymentsPayments
Series UnknownJan 14, 2026
Amount Raised: $7,000,000
Nocion Therapeutics

Cambridge, Massachusetts, United States

Nocion Therapeutics is a developer of novel pharmaceuticals intended to treat the conditions arising from neurogenic inflammation.

BiotechnologyHealth CareMedical
Series BJan 7, 2026
Amount Raised: $23,000,000
Paradigm

New York, New York, United States

Paradigm creates a platform that allow all patients to participate in clinical trials while also enhancing trial efficiency.

Health CareHealth DiagnosticsHospitalLife Science
Series BDec 4, 2025
Amount Raised: $78,000,000

Quarry Thera, a next-generation brachytherapy innovator, is advancing brachytherapy using molecular-glue technology.

Biotechnology
Series ANov 26, 2025
Amount Raised: $32,000,000
WellBeam

Palo Alto, California, United States

WellBeam is a digital-health company that provides an EMR-integrated care coordination platform.

Enterprise SoftwareHealth CareInformation TechnologySoftware
Series ANov 19, 2025
Amount Raised: $10,000,000
T-Therapeutics

Cambridge, Cambridgeshire, United Kingdom

T-Therapeutics is a next-generation T cell receptor (TCR) company spun off from the University of Cambridge.

BiotechnologyHealth CareMedical
Series ANov 13, 2025
Amount Raised: $32,000,000

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