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Two Sigma Ventures

North America, New York, United States, New York

Description

Two Sigma Ventures is the venture capital arm of Two Sigma, a prominent quantitative investment firm based in New York. Leveraging its parent company's deep expertise in data science, artificial intelligence, and advanced computing, Two Sigma Ventures primarily focuses on early-stage companies that are at the forefront of technological innovation. The firm seeks out highly driven founders building businesses that utilize data, machine learning, and computational methods to solve complex problems across various industries, including enterprise software, fintech, healthcare, and deep tech. Their investment philosophy is rooted in identifying companies with strong technical foundations and significant market potential.

The firm actively invests across Seed, Series A, and Series B stages, demonstrating a commitment to supporting companies through critical early growth phases. Two Sigma Ventures closed its fourth fund, Two Sigma Ventures IV, at a substantial $400 million in 2022, underscoring its significant capital base and capacity for impactful investments. This capital allows them to write initial checks typically ranging from $500,000 for seed-stage companies up to $10 million for more mature Series B opportunities. Beyond capital, Two Sigma Ventures provides portfolio companies with access to its extensive network, operational guidance, and the unique analytical capabilities derived from Two Sigma's core business, offering a distinct advantage in areas like data infrastructure and algorithmic development.

Their strategic approach involves not just financial backing but also providing intellectual capital and resources to help founders navigate challenges and scale effectively. The firm's deep technical roots enable them to conduct thorough due diligence on complex technologies and offer informed support to their portfolio. Two Sigma Ventures aims to be a long-term partner, often participating in follow-on rounds and leveraging its strong industry connections to facilitate growth and strategic partnerships for its portfolio companies. This blend of financial strength, technical prowess, and strategic support positions Two Sigma Ventures as a significant player in the early-stage technology investment landscape.

Investor Profile

Two Sigma Ventures has backed more than 213 startups, with 6 new investments in the last 12 months alone. The firm has led 49 rounds, about 23% of its total and boasts 24 exits across its portfolio.

Investment Focus Highlights

  • Concentrates on Series A, Seed, Series B rounds (top funding stages).
  • Majority of deals are located in United States, Canada, The Netherlands.
  • Strong thematic focus on Software, Artificial Intelligence (AI), Machine Learning.
  • Led 2 rounds in the past year.
  • Typical check size: $500K – $10M.

Stage Focus

  • Series A (31%)
  • Seed (24%)
  • Series B (20%)
  • Series C (9%)
  • Series Unknown (8%)
  • Series D (4%)
  • Series E (1%)

Country Focus

  • United States (95%)
  • Canada (1%)
  • The Netherlands (1%)
  • United Kingdom (1%)

Industry Focus

  • Software
  • Artificial Intelligence (Ai)
  • Machine Learning
  • Biotechnology
  • Information Technology
  • Health Care
  • Saas
  • Financial Services
  • Internet
  • Analytics
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FAQ

Frequently Asked Questions

Learn who this investor regularly partners with—both firms and angels—and explore their latest activity.

Who does Two Sigma Ventures frequently co-invest with?

Alexandria Venture Investments
North America, California, United States, Pasadena
Co-Investments: 11
Google Ventures
North America, California, United States, Mountain View
Co-Investments: 10
Index Ventures
North America, California, United States, San Francisco
Co-Investments: 10
Founder Collective
North America, Massachusetts, United States, Cambridge
Co-Investments: 9
Accel
North America, California, United States, Palo Alto
Co-Investments: 10
Lux Capital
North America, New York, United States, New York
Co-Investments: 14
Andreessen Horowitz
North America, California, United States, Menlo Park
Co-Investments: 13
Madrona
North America, Washington, United States, Seattle
Co-Investments: 12
Alumni Ventures
North America, New Hampshire, United States, Manchester
Co-Investments: 13
Khosla Ventures
North America, California, United States, Menlo Park
Co-Investments: 12

Which angels does Two Sigma Ventures often collaborate with?

AP
North America, New York, United States, New York
Shared Deals: 2
ZW
North America, New York, United States, New York
Shared Deals: 4
NT
North America, New York, United States, New York
Shared Deals: 3
NN
North America, Massachusetts, United States, Boston
Shared Deals: 3
AV
North America, California, United States
Shared Deals: 2
BG
North America, Washington, United States, Seattle
Shared Deals: 3
LF
North America, New York, United States, New York
Shared Deals: 3
AW
North America, California, United States, San Francisco
Shared Deals: 2
JW
North America, Florida, United States
Shared Deals: 6
SC
North America, New York, United States, New York
Shared Deals: 2

What are some of recent deals done by Two Sigma Ventures?

Bedrock Robotics

San Francisco, California, United States

Bedrock Robotics enables the construction sector to grow at the rate that modern civilization requires.

Artificial Intelligence (AI)Information TechnologyRobotics
Series AJul 16, 2025
Amount Raised: $80,000,000
NetBox Labs

New York, New York, United States

NetBox Labs develops services for the open-source NetBox IP address management and data center infrastructure management platform.

Information TechnologyOpen SourceProfessional NetworkingSaaS
Series BJul 14, 2025
Amount Raised: $35,000,000
Cerby

San Francisco, California, United States

Cerby is the identity automation platform for disconnected apps

Cloud SecurityCyber SecurityEnterprise SoftwareIdentity Management
Series BMay 28, 2025
Amount Raised: $40,000,000
Steadily

Beaverton, Oregon, United States

Steadily provides property and liability insurance for rental property owners and investors.

Commercial InsuranceInsuranceInsurTechProperty Insurance
Series CApr 23, 2025
Amount Raised: $30,000,000
Tive

Boston, Massachusetts, United States

Tive develops a hardware and software platform designed to track the conditions of shipments.

Enterprise SoftwareInternet of ThingsShippingSoftwareSupply Chain Management
Series CJan 9, 2025
Amount Raised: $40,000,000
Terray Therapeutics

Monrovia, California, United States

Terray Therapeutics is a biotechnology company that transforms small molecule drug discovery.

Artificial Intelligence (AI)BiopharmaBiotechnologyLife ScienceMedical
Series BOct 17, 2024
Amount Raised: $120,000,000
Distributional

Berkeley, California, United States

Distributional makes AI safe, reliable and secure.

A/B TestingArtificial Intelligence (AI)Information TechnologyProductivity Tools
Series AOct 8, 2024
Amount Raised: $19,000,000
Arda Therapeutics

San Francisco, California, United States

Arda is taking aim at chronic diseases and aging by eliminating the pathogenic cells that drive these conditions.

BiotechnologyHealth CareTherapeutics
Series AOct 1, 2024
Amount Raised: $43,000,000
Etched.ai

San Francisco, California, United States

Etched.ai is an AI chip startup that develops Sohu, a chip designed specifically for running transformer models.

Artificial Intelligence (AI)ComputerHardware
Series AJun 25, 2024
Amount Raised: $120,000,000
Gameto

New York, New York, United States

Gameto is a biotechnology company developing therapeutics of the female reproductive system using cell engineering.

BiopharmaBiotechnologyGeneticsLife Science
Series BMay 29, 2024
Amount Raised: $33,000,000